Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

Site-specific characterization of glycosylation requires intact glycopeptide analysis, and
recent efforts have focused on how to best interrogate glycopeptides using tandem mass …

Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids
and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is …

Glycosylation is an important posttranslational modifier of proteins and lipid conjugates
critical for the stability and function of these macromolecules. Particularly important are N …

Glycosylation is an important and variable protein modification that can have a profound
effect on the physiological characteristics of the substrate, warranting careful examination in …

The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has
been spotlighted as a factor key to facilitating infection and pathogenesis by increasing …

Alterations of protein glycosylation can serve as sensitive and specific disease biomarkers.
Labeling procedures for improved separation and detectability of oligosaccharides have …

To become established upon zoonotic transfer, influenza A viruses (IAV) need to switch
binding from “avian-type” α2-3-linked sialic acid receptors (2-3Sia) to “human-type” Siaα2-6 …

Facilitated by advances in the separation sciences, mass spectrometry and informatics,
glycoproteomics, the analysis of intact glycopeptides at scale, has recently matured enabling …