A practical guide to chimerism analysis: review of the literature and testing practices worldwide

AG Blouin, F Ye, J Williams, M Askar - Human immunology, 2021 - Elsevier
Abstract Background and Purpose Currently there are no widely accepted guidelines for
chimerism analysis testing in hematopoietic cell transplantation (HCT) patients. The …

Chimerism analysis for clinicians: a review of the literature and worldwide practices

AG Blouin, M Askar - Bone marrow transplantation, 2022 - nature.com
This review highlights literature pertinent to chimerism analysis in the context of
hematopoietic cell transplantation (HCT). We also conducted a survey of testing practices of …

Chimerism monitoring techniques after hematopoietic stem cell transplantation: an overview of the last 15 years of innovations

P Tozzo, A Delicati, R Zambello, L Caenazzo - Diagnostics, 2021 - mdpi.com
Chimerism analysis is a well-established method for monitoring the state of hematopoietic
stem cell transplantation (HSCT) over time by analyzing peripheral blood or bone marrow …

[HTML][HTML] Development and performance of a next generation sequencing (NGS) assay for monitoring of mixed chimerism

L Pettersson, F Vezzi, S Vonlanthen, K Alwegren… - Clinica Chimica …, 2021 - Elsevier
The aim of this study was to evaluate the performance of a novel NGS-based assay to
monitor mixed chimerism (MC) and compare its technical capacity to established techniques …

Lineage-specific early complete donor chimerism and risk of relapse after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia

H Lindahl, S Vonlanthen, D Valentini… - Bone Marrow …, 2022 - nature.com
Recipient–donor chimerism is routinely analyzed after allogeneic hematopoietic stem cell
transplantation (HSCT) to monitor engraftment and graft rejection. For malignancies …

[HTML][HTML] Evaluation of next-generation sequencing and crystal digital PCR for chimerism monitoring of post-allogeneic hematopoietic stem cell transplantation

P Pedini, N Cherouat, A Basire, S Simon… - … and Cellular Therapy, 2021 - Elsevier
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for most hematologic
diseases. To evaluate the level of donor engraftment, chimerism must be carefully monitored …

HLA loss and detection in the setting of relapse from HLA-mismatched hematopoietic cell transplant

PY Arnold - Human Immunology, 2022 - Elsevier
HLA loss in hematologic malignancies is rare at diagnosis but may occur in leukemic cells at
disease relapse. Although HLA mismatched hematopoietic cell transplant (HCT) is useful in …

Can novel methods replace the gold standard chimerism method after allogeneic hematopoietic stem cell transplantation?

FA Sel, FS Oğuz - Annals of Hematology, 2024 - Springer
After hematopoietic stem cell transplantation, chimerism assay is a useful approach to
monitor the success of the transplant and to select the appropriate treatment strategy, such …

[HTML][HTML] Performance Assessment of the Devyser High-Throughput Sequencing–Based Assay for Chimerism Monitoring in Patients after Allogeneic Hematopoietic …

M Vynck, F Nollet, L Sibbens, B Lievens… - The Journal of Molecular …, 2021 - Elsevier
Chimerism analysis is widely used to aid in the clinical management of patients after
allogeneic hematopoietic stem cell transplantation. Many laboratories currently use assays …

The significance of mixed chimaerism and cell lineage chimaerism monitoring in paediatric patients post haematopoietic stem cell transplant

S Kricke, K Rao, S Adams - British Journal of Haematology, 2022 - Wiley Online Library
Haematopoietic stem cell transplants (HSCTs) are carried out across the world to treat
haematological and immunological diseases which would otherwise prove fatal. Certain …