The utilization of extracellular vesicles (EVs) in wound healing has been well-documented.
However, the direct administration of free EVs via subcutaneous injection at wound sites …

MSCs are used for treatment of inflammatory conditions or for regenerative purposes. MSCs
are complete cells and allogenic transplantation is in principle possible, but mostly …

The treatment of bone defects is a difficult problem in orthopedics. At present, the treatment
mainly relies on autologous or allogeneic bone transplantation, which may lead to some …

Periodontitis, an infectious and common disease worldwide, leads to the destruction of the
periodontal ligament-alveolar bone complex. Within the bone metabolic niche …

Periodontitis is a chronic inflammatory disease that can result in the irreversible loss of tooth-
supporting tissues and elevate the likelihood and intensity of systemic diseases. The …

Background There is growing evidence that extracellular vesicles (EVs) play a crucial role in
the paracrine mechanisms of transplanted human mesenchymal stem cells (hMSCs). Little is …

Background Hydrogel carrying exosomes shows better prospects for bone regeneration.
Objective This work investigated the effect of cross-linking N-succinyl chitosan-oxidated …

We investigated the impact of mesenchymal stem cell (MSC) therapy on treating bilateral
human hip osteonecrosis, analyzing 908 cases. This study assesses factors such as tissue …

Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory, progressive
disease. However, the underlying mechanisms that aggravate femoral head necrosis remain …

In orthopedics, musculoskeletal disorders, ie, non-union of bone fractures or osteoporosis,
can have common histories and symptoms related to pathological hypoxic conditions …