Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials

M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - ASPET
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

[HTML][HTML] PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

S Rius-Pérez, I Torres-Cuevas, I Millán… - … medicine and cellular …, 2020 - hindawi.com
Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

MN Soares, M Eggelbusch, E Naddaf… - Journal of cachexia …, 2022 - Wiley Online Library
Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐
19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss …

[HTML][HTML] Mitochondrial adaptation in cancer drug resistance: Prevalence, mechanisms, and management

P Jin, J Jiang, L Zhou, Z Huang… - … of Hematology & …, 2022 - jhoonline.biomedcentral.com
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

L-carnitine and acylcarnitines: mitochondrial biomarkers for precision medicine

MR McCann, MV George De la Rosa, GR Rosania… - Metabolites, 2021 - mdpi.com
Biomarker discovery and implementation are at the forefront of the precision medicine
movement. Modern advances in the field of metabolomics afford the opportunity to readily …

[PDF][PDF] Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals

S Deota, T Lin, A Chaix, A Williams, H Le, H Calligaro… - Cell metabolism, 2023 - cell.com
Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a
daily cycle of feeding and fasting. In both animals and humans, TRF has pleiotropic health …

[HTML][HTML] The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation

MA Virmani, M Cirulli - International journal of molecular sciences, 2022 - mdpi.com
Mitochondria control cellular fate by various mechanisms and are key drivers of cellular
metabolism. Although the main function of mitochondria is energy production, they are also …

Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review …

F Battista, A Ermolao, MA van Baak… - Obesity …, 2021 - Wiley Online Library
This systematic review examined the impact of exercise intervention programs on selected
cardiometabolic health indicators in adults with overweight or obesity. Three electronic …

Atherogenic lipoprotein (a) increases vascular glycolysis, thereby facilitating inflammation and leukocyte extravasation

JG Schnitzler, RM Hoogeveen, L Ali… - Circulation …, 2020 - Am Heart Assoc
Rationale: Patients with elevated levels of lipoprotein (a)[Lp (a)] are hallmarked by
increased metabolic activity in the arterial wall on positron emission tomography/computed …

[HTML][HTML] Prehabilitation, enhanced recovery after surgery, or both? A narrative review

C Gillis, O Ljungqvist, F Carli - British journal of anaesthesia, 2022 - Elsevier
This narrative review presents a biological rationale and evidence to describe how the
preoperative condition of the patient contributes to postoperative morbidity. Any preoperative …