Activation/inactivation of anticancer drugs by CYP3A4: influencing factors for personalized cancer therapy
F Wang, X Zhang, Y Wang, Y Chen, H Lu… - Drug Metabolism and …, 2023 - ASPET
Cytochrome P450 3A4 (CYP3A4), one of the most important members of the cytochrome
P450 subfamily, is a crucial catalyst in the metabolism of numerous drugs. As it catalyzes …
P450 subfamily, is a crucial catalyst in the metabolism of numerous drugs. As it catalyzes …
Pharmacokinetic targets for therapeutic drug monitoring of small molecule kinase inhibitors in pediatric oncology
In recent years new targeted small molecule kinase inhibitors have become available for
pediatric patients with cancer. Relationships between drug exposure and treatment …
pediatric patients with cancer. Relationships between drug exposure and treatment …
[HTML][HTML] Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts
C Zhang, H Shao, D Li, N Xiao, Z Tan - BMC microbiology, 2020 - Springer
Background Although reports have provided evidence that diarrhea caused by Folium
sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial …
sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial …
Cariprazine in pediatric patients with autism spectrum disorder: results of a pharmacokinetic, safety and tolerability study
PP Yeung, KA Johnson, R Riesenberg… - Journal of Child and …, 2023 - liebertpub.com
Objective: Cariprazine is a dopamine D3-preferring D3/D2 and serotonin 5-HT1A receptor
partial agonist approved to treat adults with schizophrenia and manic/mixed or depressive …
partial agonist approved to treat adults with schizophrenia and manic/mixed or depressive …
Population pharmacokinetics of Erlotinib in patients with non–small cell Lung Cancer: its application for individualized dosing regimens in older patients
E Cardoso, M Guidi, N Khoudour… - Clinical …, 2020 - Elsevier
Purpose Erlotinib is an oral first-generation epidermal growth factor receptor (EGFR)
tyrosine kinase inhibitor approved for non–small cell lung cancers (NSCLC) with EGFR …
tyrosine kinase inhibitor approved for non–small cell lung cancers (NSCLC) with EGFR …
SAXS DATA BASED GLYCOSYLATED MODELS OF HUMAN ALPHA-1-ACID GLYCORPROTEIN, A KEY PLAYER IN HEALTH, DISEASE AND DRUG CIRCULATION
Plasma Alpha-1-glycoprotein (AGP) binds diverse drugs, its isoforms and their levels vary
significantly in acute phases of health. Relative binding of drugs to AGP and albumin has …
significantly in acute phases of health. Relative binding of drugs to AGP and albumin has …
[PDF][PDF] Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts
C Zhang, H Shao, D Li, N Xiao, Z Tan - 2020 - scholar.archive.org
Background: Although reports have provided evidence that diarrhea caused by Folium
sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial …
sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial …