Status epilepticus

DH Lowenstein, BK Alldredge - New England Journal of …, 1998 - Mass Medical Soc
A patient in status epilepticus has continuous or rapidly repeating seizures. Although the
danger of this pattern of seizure activity has been recognized since antiquity, our …

Status epilepticus: pathophysiology and management in adults

JWY Chen, CG Wasterlain - The Lancet Neurology, 2006 - thelancet.com
Summary As in Clark and Prout's classic work, we identify three phases of generalised
convulsive status epilepticus, which we call impending, established, and subtle. We review …

Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study

E Lahat, M Goldman, J Barr, T Bistritzer, M Berkovitch - Bmj, 2000 - bmj.com
Objective: To compare the safety and efficacy of midazolam given intranasally with
diazepam given intravenously in the treatment of children with prolonged febrile seizures …

Intranasal midazolam vs rectal diazepam in acute childhood seizures

M Bhattacharyya, V Kalra, S Gulati - Pediatric neurology, 2006 - Elsevier
One hundred eighty-eight seizure episodes in 46 children were randomly assigned to
receive treatment with rectal diazepam and intranasal midazolam with doses of 0.3 mg/kg …

Effects of intranasal midazolam and rectal diazepam on acute convulsions in children: prospective randomized study

T Fişgin, Y Gurer, T Tezic, N Senbil… - Journal of Child …, 2002 - journals.sagepub.com
In this study, the effects and side effects of rectal diazepam and intranasal midazolam were
compared in the treatment of acute convulsions in children to develop a practical and safe …

Midazolam as an anticonvulsant antidote for organophosphate intoxication—a pharmacotherapeutic appraisal

SD Reddy, DS Reddy - Epilepsia, 2015 - Wiley Online Library
Objective This review summarizes the therapeutic potential of midazolam as an
anticonvulsant antidote for organophosphate (OP) intoxication. Methods Benzodiazepines …

Analgesia and local anesthesia during invasive procedures in the neonate

KJS Anand, C Celeste, TF Oberlander, A Taddio… - Clinical …, 2005 - Elsevier
BACKGROUND:: Preterm and full-term neonates admitted to the neonatal intensive care unit
or elsewhere in the hospital are routinely subjected to invasive procedures that can cause …

Pharmacokinetic optimisation of benzodiazepine therapy for acute seizures: focus on delivery routes

E Rey, JM Tréluyer, G Pons - Clinical pharmacokinetics, 1999 - Springer
All benzodiazepines enter cerebral tissue rapidly. However, the duration of action is short for
diazepam (< 2 hours) and midazolam (3 to 4 hours) and longer for clonazepam (24 hours) …

A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures

A Thakker, P Shanbag - Journal of neurology, 2013 - Springer
The objective of this study is to compare the safety and efficacy of midazolam given
intranasally with diazepam given intravenously in the treatment of acute childhood seizures …

New management strategies in the treatment of status epilepticus

EM Manno - Mayo Clinic Proceedings, 2003 - Elsevier
Status epilepticus is a neurologic emergency associated with high mortality and long-term
disability. Recent advances in our understanding of the pathophysiological mechanisms …