[HTML][HTML] Memory B cells in multiple sclerosis: emerging players in disease pathogenesis

KD DiSano, F Gilli, AR Pachner - Frontiers in Immunology, 2021 - frontiersin.org
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Once thought to be primarily driven by T cells, B cells are emerging as central …

[HTML][HTML] The contribution of microglia and brain-infiltrating macrophages to the pathogenesis of neuroinflammatory and neurodegenerative diseases during TMEV …

AB DePaula-Silva - Viruses, 2024 - mdpi.com
The infection of the central nervous system (CNS) with neurotropic viruses induces
neuroinflammation and is associated with the development of neuroinflammatory and …

RETRACTED ARTICLE: Magnolol prevented brain injury through the modulation of Nrf2-dependent oxidative stress and apoptosis in PLP-induced mouse model of …

T Bibi, A Khan, AU Khan, B Shal, H Ali, EK Seo… - Naunyn-Schmiedeberg's …, 2022 - Springer
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory demyelinating disease
of the central nervous system (CNS). The aim of the current study was to investigate the …

MAP kinase inhibitor PD98059 regulates Th1, Th9, Th17, and natural T regulatory cells in an experimental autoimmune encephalomyelitis mouse model of multiple …

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - European Journal of …, 2023 - Elsevier
Experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis (MS),
provides significant insights into the mechanisms that initiate and drive autoimmunity. MS is …

The role of inflammatory mediators in epilepsy: focus on developmental and epileptic encephalopathies and therapeutic implications

A Orsini, T Foiadelli, G Costagliola, A Michev… - Epilepsy Research, 2021 - Elsevier
In recent years, there has been an increasing interest in the potential involvement of
neuroinflammation in the pathogenesis of epilepsy. Specifically, the role of innate immunity …

[HTML][HTML] The brave new world of early treatment of multiple sclerosis: Using the molecular biomarkers CXCL13 and neurofilament light to optimize immunotherapy

A Pachner - Biomedicines, 2022 - mdpi.com
Multiple sclerosis (MS) is a highly heterogeneous disease involving a combination of
inflammation, demyelination, and CNS injury. It is the leading cause of non-traumatic …

Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model

Z Wang, A Baharani, Z Wei, D Truong… - Clinical and …, 2021 - Wiley Online Library
Background Multiple sclerosis (MS) is an inflammatory demyelinating disease featured with
neuroinflammation, demyelination, and the loss of oligodendrocytes. Cognitive impairment …

[HTML][HTML] Divergent complement system activation in two clinically distinct murine models of multiple sclerosis

M Linzey, K DiSano, N Welsh, A Pachner… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS) is a neurological disease featuring neuroinflammation and
neurodegeneration in young adults. So far, most research has focused on the peripheral …

[HTML][HTML] The neuroimmunology of multiple sclerosis: fictions and facts

AR Pachner - Frontiers in Neurology, 2022 - frontiersin.org
There have been tremendous advances in the neuroimmunology of multiple sclerosis over
the past five decades, which have led to improved diagnosis and therapy in the clinic …

Theiler's Murine Encephalomyelitis Virus Replicates in Primary Neuron Cultures and Impairs Spine Density Formation

C Tomatis, A León, AOL Ortiz, P Oneto, F Fuentes… - Neuroscience, 2023 - Elsevier
In this study, we examined infection with the highly neurovirulent GDVII, the less
neurovirulent DA strains, and with a mutant DA, which lacks the L* protein (L*-1) involved in …