The misuse of sport-related gene transfer methods in elite athletes is a real and growing
concern. The success of gene therapy in the treatment of hereditary diseases has been most …

The use and utility of cochlear implantation has rapidly increased in recent years as
technological advances in the field have expanded both the efficacy and eligible patient …

The cochlea consists of multiple types of cells, including hair cells, supporting cells and
spiral ganglion neurons, and is responsible for converting mechanical forces into electric …

Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is
challenging. Systemic delivery is not effective as only a small fraction of the therapeutic …

Neonatal gene therapy has been shown to prevent inner ear dysfunction in mouse models
of Usher syndrome type I (USH1), the most common genetic cause of combined deafness …

Background TMC1 is one of the most common deafness genes causing DFNA36. Patient-
derived human induced pluripotent stem cells (iPSCs) provide an opportunity to modelling …

Viral-mediated gene augmentation, silencing, or editing offers tremendous promise for the
treatment of inherited and acquired deafness. Inner-ear gene therapies often require a safe …

The etiology of sensorineural hearing loss is heavily influenced by genetic mutations, with
approximately 80% of cases attributed to genetic causes and only 20% to environmental …

OTOF 基因突变是导致听神经病的主要因素之一, 也是隐性遗传性耳聋的常见致病基因. OTOF
基因编码的耳畸蛋白(otoferlin) 参与Ca2+ 相关内毛细胞突触囊泡的融合及神经递质的释放 …

Middle ear ailments include a broad range of pathological conditions. Otitis media is the
leading middle ear disease of childhood, which incurs significant health care resources in …