Pharmacological effects of cannabidiol by transient receptor potential channels

L Etemad, G Karimi, MS Alavi, A Roohbakhsh - Life Sciences, 2022 - Elsevier
Cannabidiol (CBD), as a major phytocannabinoid of Cannabis sativa, has emerged as a
promising natural compound in the treatment of diseases. Its diverse pharmacological …

Emerging therapeutic potential of cannabidiol (CBD) in neurological disorders: a comprehensive review

K Singh, B Bhushan, DK Chanchal… - Behavioural …, 2023 - Wiley Online Library
Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its
potential therapeutic applications. This thorough analysis explores the increasing …

Clinical and cognitive improvement following full-spectrum, high-cannabidiol treatment for anxiety: open-label data from a two-stage, phase 2 clinical trial

MK Dahlgren, AM Lambros, RT Smith… - Communications …, 2022 - nature.com
Background Evidence suggests cannabidiol (CBD) has anxiolytic properties, indicating
potential for novel treatment strategies. However, few clinical trials of CBD-based products …

[HTML][HTML] Alleviating anxiety and taming trauma: novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder

N Singewald, SB Sartori, A Reif, A Holmes - Neuropharmacology, 2023 - Elsevier
Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …

Cannabidiol goes nuclear: The role of PPARγ

S Khosropoor, MS Alavi, L Etemad, A Roohbakhsh - Phytomedicine, 2023 - Elsevier
Background Cannabidiol (CBD) is one of the main phytocannabinoids found in Cannabis
sativa. In contrast to Δ9-tetrahydrocannabinol, it has a low affinity for cannabinoid receptors …

Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze

D Fabris, MC Carvalho, ML Brandão… - Journal of …, 2022 - journals.sagepub.com
Rationale: Cannabidiol (CBD), the major non-psychoactive constituent of cannabis, has
therapeutic potential for the treatment of anxiety. Most preclinical studies investigate only …

Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT1A but not CB1 or CB2 receptors

JM Franzen, I Werle, F Vanz, BB de Oliveira… - …, 2023 - Elsevier
Growing evidence from male rodent and human studies suggests that cannabidiol (CBD)
modulates the expression of aversive memories and anxiety-related responses. The limited …

Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled …

EA Silva Junior, WMB Medeiros, JPM Santos… - Trends in Psychiatry …, 2024 - SciELO Brasil
Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social
communication and social interaction and by restricted and repetitive patterns of behavior …

Binge-like alcohol exposure in adolescence: behavioural, neuroendocrine and molecular evidence of abnormal neuroplasticity… and return

A Brancato, V Castelli, G Lavanco, G Tringali, V Micale… - Biomedicines, 2021 - mdpi.com
Binge alcohol consumption among adolescents affects the developing neural networks
underpinning reward and stress processing in the nucleus accumbens (NAc). This study …

Current state of cannabis use, policies, and research across sixteen countries: cross-country comparisons and international perspectives

R Ransing, PA De la Rosa… - Trends in psychiatry …, 2022 - SciELO Brasil
Introduction Varying public views on cannabis use across countries may explain the
variation in the prevalence of use, policies, and research in individual countries, and global …