Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

The soluble epoxide hydrolase appears to be a promising target for the development of
antihypertensive therapies based on a previously unexplored mechanism of action. Epoxide …

Epoxyeicosatrienoic acids (EETs) are metabolized by soluble epoxide hydrolase (sEH) to
form dihydroxyeicosatrienoic acids (DHETs) and are putative endothelium-derived …

Arachidonic acid metabolites, eicosanoids, are key contributors to vascular function and
improper eicosanoid regulation contributes to the progression of cardiovascular diseases …

Various members of the cytochrome P450 (CYP) superfamily have the capacity of
metabolizing omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFAs). In …

Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by
cytochrome P450 (CYP) epoxygenases. The activation of CYP epoxygenases in endothelial …

All-cis-14, 15-epoxyeicosa-5, 8, 11-trienoic acid (14, 15-EET) is a labile, vasodilatory
eicosanoid generated from arachidonic acid by cytochrome P450 epoxygenases. A series of …

Activation of metabotropic glutamate receptors (mGluRs) located on astrocytic projections
that surround synapses of glutamatergic neurons results in an increase in cytosolic calcium …

Toxicologic and physiologic roles of CYP1A enzyme induction, the major biochemical effect
of aryl hydrocarbon receptor activation by TCDD and other receptor ligands, are unknown …

Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid by cytochrome P450
epoxygenases, are potent vasodilators that function as endothelium-derived hyperpolarizing …