Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy
Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens
worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to …
worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to …
The use of noncarbapenem β-lactams for the treatment of extended-spectrum β-lactamase infections
PD Tamma, J Rodriguez-Baňo - Clinical Infectious Diseases, 2017 - academic.oup.com
The continued rise in infections caused by extended-spectrum β-lactamase (ESBL)–
producing pathogens is recognized globally as one of the most pressing concerns facing the …
producing pathogens is recognized globally as one of the most pressing concerns facing the …
Ceftolozane/tazobactam: place in therapy
DR Giacobbe, M Bassetti, FG De Rosa… - Expert review of anti …, 2018 - Taylor & Francis
ABSTRACT Introduction: Ceftolozane/tazobactam (C/T) is a new antibiotic resulting from the
combination of a novel cephalosporin, structurally similar to ceftazidime, with tazobactam, a …
combination of a novel cephalosporin, structurally similar to ceftazidime, with tazobactam, a …
[HTML][HTML] Augmented renal clearance and how to augment antibiotic dosing
IH Chen, DP Nicolau - Antibiotics, 2020 - mdpi.com
Augmented renal clearance (ARC) refers to the state of heightened renal filtration commonly
observed in the critically ill. Its prevalence in this patient population is a consequence of the …
observed in the critically ill. Its prevalence in this patient population is a consequence of the …
[HTML][HTML] Bench-to-bedside review: appropriate antibiotic therapy in severe sepsis and septic shock–does the dose matter?
F Pea, P Viale - Critical Care, 2009 - Springer
Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean
prompt achievement and maintenance of optimal exposure at the infection site with broad …
prompt achievement and maintenance of optimal exposure at the infection site with broad …
Antimicrobial stewardship: concepts and strategies in the 21st century
RC Owens Jr - Diagnostic microbiology and infectious disease, 2008 - Elsevier
Large worldwide surveillance studies report that resistance to nearly all classes of
antimicrobial is increasing, as is the emergence of what have been termed pan-drug …
antimicrobial is increasing, as is the emergence of what have been termed pan-drug …
Piperacillin/tazobactam Susceptibility Test Interpretive Criteria for Enterobacterales: Recommendations from the United States Committee on Antimicrobial …
TP Lodise, SM Bhavnani, PG Ambrose… - Clinical Infectious …, 2024 - academic.oup.com
The in vitro susceptibility testing interpretive criteria (STIC) for TZP against Enterobacterales
were recently updated by the Food and Drug Administration (FDA), Clinical & Laboratory …
were recently updated by the Food and Drug Administration (FDA), Clinical & Laboratory …
[HTML][HTML] Management of infections pre-and post-liver transplantation: report of an AISF consensus conference
The burden of infectious diseases both before and after liver transplantation is clearly
attributable to the dysfunction of defensive mechanisms of the host, both as a result of …
attributable to the dysfunction of defensive mechanisms of the host, both as a result of …
Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusion
L Lorente, A Jiménez, MM Martín, JL Iribarren… - International journal of …, 2009 - Elsevier
The standard mode of administration of piperacillin treatment is by intermittent infusion.
However, continuous infusion may be advantageous as β-lactam antibiotics exhibit time …
However, continuous infusion may be advantageous as β-lactam antibiotics exhibit time …
Population pharmacokinetics of high-dose, prolonged-infusion cefepime in adult critically ill patients with ventilator-associated pneumonia
AM Nicasio, RE Ariano, SA Zelenitsky… - Antimicrobial agents …, 2009 - Am Soc Microbiol
ABSTRACT A population pharmacokinetic model of cefepime was constructed from data
from adult critical care patients with ventilator-associated pneumonia (VAP). A total of 32 …
from adult critical care patients with ventilator-associated pneumonia (VAP). A total of 32 …