Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens
worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to …

The continued rise in infections caused by extended-spectrum β-lactamase (ESBL)–
producing pathogens is recognized globally as one of the most pressing concerns facing the …

ABSTRACT Introduction: Ceftolozane/tazobactam (C/T) is a new antibiotic resulting from the
combination of a novel cephalosporin, structurally similar to ceftazidime, with tazobactam, a …

Augmented renal clearance (ARC) refers to the state of heightened renal filtration commonly
observed in the critically ill. Its prevalence in this patient population is a consequence of the …

Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean
prompt achievement and maintenance of optimal exposure at the infection site with broad …

Large worldwide surveillance studies report that resistance to nearly all classes of
antimicrobial is increasing, as is the emergence of what have been termed pan-drug …

The in vitro susceptibility testing interpretive criteria (STIC) for TZP against Enterobacterales
were recently updated by the Food and Drug Administration (FDA), Clinical & Laboratory …

The burden of infectious diseases both before and after liver transplantation is clearly
attributable to the dysfunction of defensive mechanisms of the host, both as a result of …

The standard mode of administration of piperacillin treatment is by intermittent infusion.
However, continuous infusion may be advantageous as β-lactam antibiotics exhibit time …

ABSTRACT A population pharmacokinetic model of cefepime was constructed from data
from adult critical care patients with ventilator-associated pneumonia (VAP). A total of 32 …