A DNA nanoraft-based cytokine delivery platform for alleviation of acute kidney injury

W Li, C Wang, H Lv, Z Wang, M Zhao, S Liu, L Gou… - Acs Nano, 2021 - ACS Publications
Cytokine immunotherapy represents an attractive strategy to stimulate robust immune
responses for renal injury repair in ischemic acute kidney injury (AKI). However, its clinical …

DNA nanolithography enables a highly ordered recognition interface in a microfluidic chip for the efficient capture and release of circulating tumor cells

J Zhang, B Lin, L Wu, M Huang, X Li… - Angewandte …, 2020 - Wiley Online Library
Microfluidic chips with nano‐scale structures have shown great potential, but the fabrication
and cost issues restrict their application. Herein, we propose a conceptually new “DNA …

Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis

S Sirong, C Yang, T Taoran, L Songhang, L Shiyu… - Bone research, 2020 - nature.com
Osteoarthritis, a disorder characterized by articular cartilage deterioration, varying degrees
of inflammation, and chondrocyte apoptosis, is the most common chronic joint disease. To …

Bubble-propelled jellyfish-like micromotors for DNA sensing

X Zhang, C Chen, J Wu, H Ju - ACS applied materials & interfaces, 2019 - ACS Publications
A chemically powered jellyfish-like micromotor was proposed by using a multimetallic shell
and a DNA assembly with catalase decorations modified on the concave surface to simulate …

Antioxidative and angiogenesis-promoting effects of tetrahedral framework nucleic acids in diabetic wound healing with activation of the Akt/Nrf2/HO-1 pathway

S Lin, Q Zhang, S Li, T Zhang, L Wang… - … applied materials & …, 2020 - ACS Publications
Currently available strategies show limited effects in preventing morbidity and disability from
chronic diabetic wounds. Ideal vascularization is indispensable for better restoration and …

Capturing transient antibody conformations with DNA origami epitopes

P Zhang, X Liu, P Liu, F Wang, H Ariyama… - Nature …, 2020 - nature.com
Revealing antibody-antigen interactions at the single-molecule level will deepen our
understanding of immunology. However, structural determination under crystal or cryogenic …

Logic‐Gated Proximity Aptasensing for Cell‐Surface Real‐Time Monitoring of Apoptosis

J Zheng, Q Wang, L Shi, P Peng… - Angewandte Chemie …, 2021 - Wiley Online Library
In nature, intact apoptotic cells release ATP as a signaling molecule to trigger prompt
phagocytic clearance, even at the earliest stage of apoptosis. Inspired by this, here we …

DNA framework-engineered chimeras platform enables selectively targeted protein degradation

L Zhou, B Yu, M Gao, R Chen, Z Li, Y Gu, J Bian… - Nature …, 2023 - nature.com
A challenge in developing proteolysis targeting chimeras (PROTACs) is the establishment of
a universal platform applicable in multiple scenarios for precise degradation of proteins of …

Ultrasensitive exosomal microRNA detection with a supercharged DNA framework nanolabel

N Liu, H Lu, L Liu, W Ni, Q Yao, GJ Zhang… - Analytical …, 2021 - ACS Publications
DNA self-assembly has created various nanostructured probes deployed in biosensors,
whereas their direct charge contribution to sensitive bioassays remains elusive. Here, we …

DNA-based molecular machines

X Mao, M Liu, Q Li, C Fan, X Zuo - JACS Au, 2022 - ACS Publications
Artificial molecular machines have found widespread applications ranging from fundamental
studies to biomedicine. More recent advances in exploiting unique physical and chemical …