[HTML][HTML] Gadolinium deposition in the brain: current updates

JW Choi, WJ Moon - Korean journal of radiology, 2019 - synapse.koreamed.org
Gadolinium-based contrast agents (GBCAs) are commonly used for enhancement in MR
imaging and have long been considered safe when administered at recommended doses …

[HTML][HTML] Gadolinium: pharmacokinetics and toxicity in humans and laboratory animals following contrast agent administration

J Davies, P Siebenhandl-Wolff, F Tranquart… - Archives of …, 2022 - Springer
Gadolinium-based contrast agents (GBCAs) have transformed magnetic resonance imaging
(MRI) by facilitating the use of contrast-enhanced MRI to allow vital clinical diagnosis in a …

[HTML][HTML] Quantification and assessment of the chemical form of residual gadolinium in the brain after repeated administration of gadolinium-based contrast agents …

T Frenzel, C Apte, G Jost, L Schöckel… - Investigative …, 2017 - journals.lww.com
Objective Multiple clinical and preclinical studies have reported a signal intensity increase
and the presence of gadolinium (Gd) in the brain after repeated administration of Gd-based …

[HTML][HTML] Histology and gadolinium distribution in the rodent brain after the administration of cumulative high doses of linear and macrocyclic gadolinium-based contrast …

J Lohrke, AL Frisk, T Frenzel, L Schöckel… - Investigative …, 2017 - journals.lww.com
Objectives Retrospective studies in patients with primary brain tumors or other central
nervous system pathologies as well as postmortem studies have suggested that gadolinium …

One-year retention of gadolinium in the brain: comparison of gadodiamide and gadoterate meglumine in a rodent model

P Robert, S Fingerhut, C Factor, V Vives, J Letien… - Radiology, 2018 - pubs.rsna.org
Purpose To compare the long-term brain elimination kinetics and gadolinium species in
healthy rats after repeated injections of the contrast agents gadodiamide (a linear contrast …

Long-term excretion of gadolinium-based contrast agents: linear versus macrocyclic agents in an experimental rat model

G Jost, T Frenzel, J Boyken, J Lohrke, V Nischwitz… - Radiology, 2019 - pubs.rsna.org
Purpose To investigate the long-term course of MRI signal intensity (SI) changes and the
presence of gadolinium in the rat brain during a 1-year period after multiple administrations …

Gadolinium retention in the rat brain: assessment of the amounts of insoluble gadolinium-containing species and intact gadolinium complexes after repeated …

E Gianolio, P Bardini, F Arena, R Stefania… - Radiology, 2017 - pubs.rsna.org
Purpose To evaluate the speciation of gadolinium-containing species after multiple
administrations of the gadolinium-based contrast agents (GBCAs) gadodiamide and …

Retention of gadolinium in brain parenchyma: pathways for speciation, access, and distribution. A critical review

M Rasschaert, RO Weller, JA Schroeder… - Journal of Magnetic …, 2020 - Wiley Online Library
The unexpected appearance of T1 hyperintensities, mostly in the dentate nucleus and the
globus pallidus, during nonenhanced MRI was reported in 2014. This effect is associated …

Gadolinium retention in the body: what we know and what we can do

E Tedeschi, F Caranci, F Giordano, V Angelini… - La radiologia …, 2017 - Springer
Gadolinium-based contrast agents (GBCA), widely used in Magnetic Resonance Imaging
(MRI) for almost 30 years, were recently shown to be deposited in the brain and to induce …

Gadolinium-based contrast agents—review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on …

E Blumfield, DW Swenson, RS Iyer, AL Stanescu - Pediatric radiology, 2019 - Springer
Gadolinium has been used as a base for contrast agents in MRI for the last three decades.
Numerous studies over the last 4 years have reported increased signal intensity in deep …