Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …

The presentation of peptides to T cells by MHC class II molecules is of critical importance in
specific recognition by the immune system. Expression of class II molecules is exquisitely …

Dendritic cells are the most efficient antigen-presenting cells. They take up antigens and
pathogens, generate MHC–peptide complexes, migrate from the sites of antigen acquisition …

From HIV to influenza, the battle between infectious agents and the immune system is at the
heart of disease. Knowledge of how and why parasites vary to escape recognition by the …

Protein therapeutics have drastically changed the landscape of treatment for many diseases
by providing a regimen that is highly specific and lacks many off-target toxicities. The clinical …

Immature dendritic cells (DCs) sample their environment for antigens and after stimulation
present peptide associated with major histocompatibility complex class II (MHC II) to naive T …

Dendritic cells (DCs) are central to the maintenance of immunological tolerance and the
initiation and control of immunity. The antigen-presenting properties of DCs enable them to …

Tapasin is a component of the major histocompatibility complex (MHC) class I antigen-
loading complex. Here we show that mice with a disrupted tapasin gene display reduced …

The function of MHC class II molecules is to bind peptides derived from antigens that access
the endocytic route of antigen presenting cells and display them on the plasma membrane …

We have investigated the mechanisms that control MHC class II (MHC II) expression in
immature and activated dendritic cells (DC) grown from spleen and bone marrow …