Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that
leads to cognitive impairment and memory loss. Emerging evidence suggests that …

This review discusses the driving principles that may underlie neurodegeneration in
dementia, represented most dominantly by Alzheimer's disease (AD). While a myriad of …

Alzheimer's disease (AD) is an irreversible neurodegenerative disease that affects millions
of people worldwide. AD does not have a cure and most drug development efforts in the AD …

Alzheimer's disease (AD) is a neurodegenerative disease, caused by poorly known
pathogenic mechanisms and aggravated by delayed therapeutic intervention, that still lacks …

Introduction Recent neuroscience breakthroughs have shed light on the sophisticated
relationship between calcium channelopathies and movement disorders, exposing a …

Ryanodine receptors (RyR) are intracellular Ca 2+ channels localized in the endoplasmic
reticulum, where they act as critical mediators of Ca 2+-induced Ca 2+ calcium release …

Hippocampal synaptic plasticity is widely considered the cellular basis of learning and
spatial memory processes. This article highlights the central role of Ca 2+ release from the …

Alzheimer's disease (AD) is the most common cause of dementia. There is a growing body
of evidence that dysregulation in neuronal calcium (Ca2+) signaling plays a major role in the …

Alzheimer's disease (AD) is associated with brain accumulation of synaptotoxic amyloid-β
(Aβ) peptides produced by the proteolytic processing of amyloid precursor protein (APP) …

This review rigorously investigates the early cerebral changes associated with Alzheimer's
disease, which manifest long before clinical symptoms arise. It presents evidence that the …