Although the urinary bladder urothelium has classically been thought of as a passive barrier
to ions and solutes, a number of novel properties have been recently attributed to urothelial …

Beyond serving as a simple barrier, there is growing evidence that the urinary bladder
urothelium exhibits specialized sensory properties and play a key role in the detection and …

The urinary bladder “mucosa” or innermost portion of the bladder is composed of transitional
epithelium, basement membrane, and the lamina propria. This chapter reviews the …

Human bladder contraction mainly depends on Ca2+ influx via L-type voltage-gated Ca2+
channels and on RhoA/Rho kinase contractile signaling, which is upregulated in overactive …

Bladder diseases affect millions of patients worldwide and compromise their quality of life
with a substantial economic impact. The not fully understood aetiologies of bladder diseases …

Objectives: Incidences of overactive bladder (OAB) and cognitive dysfunction increase with
aging. Treatment of OAB with antimuscarinic agents may result in cognitive decline …

Objective: To evaluate adherence with overactive bladder (OAB) pharmacotherapy and
compare costs between patients receiving pharmacotherapy versus nonpharmacologic …

Disclosed herein are pharmaceutical compositions compris ing combinations oftolterodine,
an antimuscarinic agent, and pilocarpine, a compound that causes stimulation of salivary …

Background: Urinary incontinence (UI) has been identified as a World Health Organization
health priority. In particular, urge UI (UUI) refers to urine leakage associated with a sudden …

Disclosed herein are pharmaceutical compositions compris ing oxybutynin, or a free base
thereof or a pharmaceutically acceptable salt thereof, and pilocarpine, or a free base thereof …