The changing therapeutic landscape of head and neck cancer

JD Cramer, B Burtness, QT Le, RL Ferris - Nature reviews Clinical …, 2019 - nature.com
Head and neck cancers are a heterogeneous collection of malignancies of the upper
aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the …

The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

E Benson, R Li, D Eisele, C Fakhry - Oral oncology, 2014 - Elsevier
Human papillomavirus (HPV) is etiologically responsible for a distinct subset of head and
neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most …

Deintensification candidate subgroups in human papillomavirus–related oropharyngeal cancer according to minimal risk of distant metastasis

B O'Sullivan, SH Huang, LL Siu, J Waldron… - Journal of clinical …, 2013 - ascopubs.org
Purpose To define human papillomavirus (HPV)–positive oropharyngeal cancers (OPC)
suitable for treatment deintensification according to low risk of distant metastasis (DM) …

Pretreatment identification of head and neck cancer nodal metastasis and extranodal extension using deep learning neural networks

BH Kann, S Aneja, GV Loganadane, JR Kelly… - Scientific reports, 2018 - nature.com
Identification of nodal metastasis and tumor extranodal extension (ENE) is crucial for head
and neck cancer management, but currently only can be diagnosed via postoperative …

Multi-institutional validation of deep learning for pretreatment identification of extranodal extension in head and neck squamous cell carcinoma

BH Kann, DF Hicks, S Payabvash… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Extranodal extension (ENE) is a well-established poor prognosticator and an
indication for adjuvant treatment escalation in patients with head and neck squamous cell …

A systematic review of transoral robotic surgery and radiotherapy for early oropharynx cancer: a systematic review

JR De Almeida, JK Byrd, R Wu, CL Stucken… - The …, 2014 - Wiley Online Library
Objectives/Hypothesis To demonstrate the comparative effectiveness of transoral robotic
surgery (TORS) to intensity modulated radiotherapy (IMRT) for early T‐stage oropharyngeal …

Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8+ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer …

R Ferrarotto, D Bell, ML Rubin, KA Hutcheson… - Clinical Cancer …, 2020 - AACR
Purpose: In oropharyngeal squamous cell carcinoma (OPC), high CD8+ tumor-infiltrating
lymphocyte (CD8+ TIL) density confers improved prognosis. We compared neoadjuvant …

Prognostic factors and survival unique to surgically treated p16+ oropharyngeal cancer

BH Haughey, P Sinha - The Laryngoscope, 2012 - Wiley Online Library
Abstract Objectives/Hypothesis: Current head and neck epidemiology demonstrates a
steadily increasing incidence of p16+ human papillomavirus‐related oropharynx squamous …

The diagnostic performance of CT and MRI for detecting extranodal extension in patients with head and neck squamous cell carcinoma: a systematic review and …

SI Park, JP Guenette, CH Suh, GJ Hanna… - European …, 2021 - Springer
Objective To review the diagnostic performance of CT and MRI for detecting extranodal
extension (ENE) in head and neck squamous cell carcinoma (HNSCC) patients. Methods …

The role of transoral robotic surgery in the management of oropharyngeal cancer: a review of the literature

SA Dowthwaite, JH Franklin, DA Palma… - International …, 2012 - Wiley Online Library
Background. Transoral robotic surgery (TORS) is an emerging treatment option for the
treatment of head and neck malignancies, particularly for oropharyngeal squamous cell …