Barriers and opportunities for the clinical implementation of therapeutic drug monitoring in oncology
BD Menz, SL Stocker, N Verougstraete… - British Journal of …, 2021 - Wiley Online Library
There are few fields of medicine in which the individualisation of medicines is more
important than in the area of oncology. Under‐dosing can have significant ramifications due …
important than in the area of oncology. Under‐dosing can have significant ramifications due …
[HTML][HTML] Impact of pharmacokinetic and pharmacodynamic properties of monoclonal antibodies in the management of psoriasis
K Rodríguez-Fernández, V Mangas-Sanjuán… - Pharmaceutics, 2022 - mdpi.com
The treatment of psoriasis has been revolutionized by the emergence of biological
therapies. Monoclonal antibodies (mAb) generally have complex pharmacokinetic (PK) …
therapies. Monoclonal antibodies (mAb) generally have complex pharmacokinetic (PK) …
[HTML][HTML] Antibody-based therapeutic interventions for amyotrophic lateral sclerosis: a systematic literature review
Amyotrophic Lateral Sclerosis (ALS) is a mid-life onset neurodegenerative disease that
manifests its symptomatology with motor impairments and cognitive deficits overlapping with …
manifests its symptomatology with motor impairments and cognitive deficits overlapping with …
[HTML][HTML] Importance and considerations of antibody engineering in antibody-drug conjugates development from a clinical pharmacologist's perspective
AT Lucas, A Moody, AN Schorzman, WC Zamboni - Antibodies, 2021 - mdpi.com
Antibody-drug conjugates (ADCs) appear to be in a developmental boom, with five FDA
approvals in the last two years and a projected market value of over $4 billion by 2024 …
approvals in the last two years and a projected market value of over $4 billion by 2024 …
[HTML][HTML] Mechanisms of action of the new antibodies in use in multiple myeloma
A Romano, P Storti, V Marchica, G Scandura… - Frontiers in …, 2021 - frontiersin.org
Monoclonal antibodies (mAbs) directed against antigen-specific of multiple myeloma (MM)
cells have Fc-dependent immune effector mechanisms, such as complement-dependent …
cells have Fc-dependent immune effector mechanisms, such as complement-dependent …
[HTML][HTML] Investigating the influence of drone flight on the stability of cancer medicines
Monoclonal Antibodies (mAbs) are being used in the treatment of both malignant and non-
malignant diseases and whilst highly effective, certain products have very short expiry times …
malignant diseases and whilst highly effective, certain products have very short expiry times …
[HTML][HTML] Stability of Medicines Transported by Cargo Drones: Investigating the Effects of Vibration from Multi-Stage Flight
The timely distribution of medicines to patients is an essential part of the patient care plan,
and maximising efficiency in the logistics systems behind these movements is vital to …
and maximising efficiency in the logistics systems behind these movements is vital to …
Utility, promise, and limitations of liquid chromatography‐mass spectrometry‐based therapeutic drug monitoring in precision medicine
VP Gaspar, S Ibrahim, RP Zahedi… - Journal of Mass …, 2021 - Wiley Online Library
Therapeutic drug monitoring (TDM) is typically referred to as the measurement of the
concentration of drugs in patient blood. Although in the past, TDM was restricted to drugs …
concentration of drugs in patient blood. Although in the past, TDM was restricted to drugs …
Development of an efficient mAb quantification assay by LC-MS/MS using rapid on-bead digestion
HH Chiu, YJ Tsai, C Lo, CH Lin, IL Tsai, CH Kuo - Analytica Chimica Acta, 2022 - Elsevier
The use of monoclonal antibody (mAb) therapeutics is increasing rapidly, but mAb
concentrations vary widely between individuals and might subsequently affect mAb …
concentrations vary widely between individuals and might subsequently affect mAb …
Microporous affinity membranes and their incorporation into microfluidic devices for monitoring of therapeutic antibodies
Control of monoclonal antibody (mAb) concentrations in serum is important for maintaining
the safety and efficacy of these lifesaving therapeutics. Point-of-care (POC) quantification of …
the safety and efficacy of these lifesaving therapeutics. Point-of-care (POC) quantification of …