Progranulin (PGRN) is an autocrine growth factor with multiple functions. This review
provides updates about the interplays of PGRN with extracellular matrix proteins, proteolytic …

Considered for decades as a cartilage disease, recent studies of osteoarthritis (OA) take us
back to the concepts discussed at the naming of the disorder as “bone-joint-inflammation” …

Cellular senescence is closely related to tissue aging including bone. Bone homeostasis is
maintained by the tight balance between bone-forming osteoblasts and bone-resorbing …

Chronic musculoskeletal pain affects all aspects of human life. However, mechanisms of its
genetic control remain poorly understood. Genetic studies of pain are complicated by the …

Increasing evidence suggests critical functions of thrombospondins (TSPs) in a variety of
physiological and pathological processes. With the growing understanding of the …

Thrombospondins (TSPs) belong to a functional class of ECM proteins called matricellular
proteins that are not primarily structural, but instead influence cellular interactions within the …

Lichen sclerosus (LS) is an acquired chronic inflammatory dermatosis predominantly
affecting the anogenital area with recalcitrant itching and soreness. Progressive or persistent …

Introduction The prevalence of heart failure increases in the aging population and following
myocardial infarction (MI), yet the extracellular matrix (ECM) remodeling underpinning the …

Background An increasing body of evidence supports an essential role for endoplasmic
reticulum stress (ERS) in colorectal cancer (CRC). In this study, we developed an ERS …

Context Gait biomechanics are linked to biochemical changes that contribute to the
development of posttraumatic knee osteoarthritis in individuals with anterior cruciate …