New insights into abasic site repair and tolerance
PS Thompson, D Cortez - DNA repair, 2020 - Elsevier
Thousands of apurinic/apyrimidinic (AP or abasic) sites form in each cell, each day. This
simple DNA lesion can have profound consequences to cellular function, genome stability …
simple DNA lesion can have profound consequences to cellular function, genome stability …
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications
Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …
Replication-coupled DNA-protein crosslink repair by SPRTN and the proteasome in Xenopus egg extracts
NB Larsen, AO Gao, JL Sparks, I Gallina, RA Wu… - Molecular cell, 2019 - cell.com
DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …
The CMG helicase bypasses DNA-protein cross-links to facilitate their repair
Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten
genome integrity. Using Xenopus egg extracts, we previously showed that replication fork …
genome integrity. Using Xenopus egg extracts, we previously showed that replication fork …
DNA–protein crosslink proteases in genome stability
A Ruggiano, K Ramadan - Communications Biology, 2021 - nature.com
Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
Isolation and detection of DNA–protein crosslinks in mammalian cells
I Torrecilla, A Ruggiano, K Kiianitsa… - Nucleic Acids …, 2024 - academic.oup.com
DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …
FAM111A protects replication forks from protein obstacles via its trypsin-like domain
Y Kojima, Y Machida, S Palani, TR Caulfield… - Nature …, 2020 - nature.com
Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and
tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the …
tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the …
[HTML][HTML] The hammer and the dance of cell cycle control
A Panagopoulos, M Altmeyer - Trends in biochemical sciences, 2021 - cell.com
Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next.
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …
TEX264 coordinates p97-and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
Abstract Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient
DNA replication and transcription. TOP1 is also a major driver of endogenous genome …
DNA replication and transcription. TOP1 is also a major driver of endogenous genome …
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are
covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer …
covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer …