Nowadays acute myocardial infarction (AMI) is a serious cardiovascular disease threatening
the human life and health worldwide. The most effective treatment is to quickly restore …

Fibrosis usually results from dysregulated wound repair and is characterized by excessive
scar tissue. It is a complex process with unclear mechanisms. Accumulating evidence …

The incidence and prevalence of cardiac diseases, which are the main cause of death
worldwide, are likely to increase because of population ageing. Prevailing theories about …

Reversible protein acetylation provides a central mechanism for controlling gene expression
and cellular signaling events. Two pharmacological inhibitors of protein deacetylation are …

Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

Fibrosis, which is defined as excessive accumulation of fibrous connective tissue,
contributes to the pathogenesis of numerous diseases involving diverse organ systems …

Background—Atrial fibrillation (AF) is characterized by structural remodeling, contractile
dysfunction, and AF progression. Histone deacetylases (HDACs) influence acetylation of …

This Perspective provides an in depth look at the numerous disease states in which histone
deacetylase 6 (HDAC6) has been implicated. The physiological pathways, protein–protein …

Histone deacetylases (HDACs) deacetylate histones and non‐histone proteins, thereby
affecting protein activity and gene expression. The regulation and function of the cytoplasmic …

BACKGROUND: Patients with a history of hypertension have elevated inflammation and a
worse prognosis after acute myocardial infarction (AMI). Regulatory T cells (Tregs) are …