Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround
specific neurons in the brain and spinal cord, appear during critical periods of development …

Alzheimer's disease (AD) is a neurodegenerative disease with complex pathological
characteristics, whose etiology and pathogenesis are still unclear. Over the past few …

The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known
for its involvement in glucose sensing and whole-body glucose homeostasis. However, it is …

At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for
robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the …

Perineuronal nets (PNNs) are chondroitin-sulfate glycosaminoglycan (CS-GAG) containing
extracellular matrix structures that assemble around neurons involved in learning, memory …

As chemically specialized forms of the extracellular matrix in the central nervous system,
polyanionic perineuronal nets (PNs) contain diverse constituents including chondroitin …

HIV-associated neurocognitive disorder (HAND) is characterized by cognitive and
behavioral deficits in people living with HIV. HAND is still common in patients that take …