The excitatory‐inhibitory imbalance has been considered an important mechanism
underlying stress‐related psychiatric disorders. In the present study, rats were exposed to 6 …

Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity
and synapse dynamics. PNNs have been shown to have effects on memory formation …

Through research into the molecular and cellular mechanisms that occur during critical
periods, recent experimental neurobiological data have brought to light the importance of …

Psychological loss is a common experience that erodes well-being and negatively impacts
quality of life. The molecular underpinnings of loss are poorly understood. Here, we …

Affective state encompasses emotional responses to our physiology and influences how we
perceive and respond within our environment. In affective disorders such as depression …

Infiltration of peripheral immune cells after blood-brain barrier dysfunction causes severe
inflammation after a stroke. Although the endothelial glycocalyx, a network of membrane …

Abstract Mutations in the Euchromatic Histone Methyltransferase 1 (EHMT1) gene cause
Kleefstra syndrome, a rare form of intellectual disability (ID) with strong autistic traits and …

Microglia play numerous important roles in brain development. From early embryonic stages
through adolescence, these immune cells influence neuronal genesis and maturation, guide …

Background Alzheimer's disease (AD) is associated with gradual memory loss and anxiety
which affects~ 75% of AD patients. This study investigated whether AD‐associated anxiety …

Age-related hearing loss, one of the most frequently diagnosed disabilities in industrialized
countries, may result from declining levels of GABA in the aging inferior colliculus (IC) …