Tau mutations promote the formation of tau oligomers and filaments, which are
neuropathological signs of several tau-associated dementias. Types of neurons in the CNS …

Perineuronal nets (PNNs) are extracellular matrix assemblies of highly negatively charged
proteoglycans that wrap around fast-spiking parvalbumin (PV) expressing interneurons in …

Following a spinal cord injury (SCI), chondroitin sulfate proteoglycans (CSPGs) are up-
regulated at the glial scar inhibiting neuroregeneration. Under normal physiological …

At neuronal synapses, synaptic vesicles (SVs) require glycoproteins for normal trafficking,
and N-linked glycosylation is required for delivery of the major SV glycoproteins …

ABSTRACT Semaphorin 3A (Sema3A) is a secreted protein that signals to cells through
binding to neuropilin and plexin receptors and provides neurons with guidance cues key for …

Psychological loss is a common experience that erodes well-being and negatively impacts
quality of life. The molecular underpinnings of loss are poorly understood, making it …

Alzheimer's disease is one of the most common causes of dementia and is a
neurodegenerative disease that occurs with memory loss, loss of language, thinking and …

A number of regulatory players in minor glucose metabolic pathways, such as folate and
chondroitin sulfate proteoglycans, have recently been identified as potential targets to …

The 6-OHDA mouse model recapitulates midbrain dopaminergic cell loss and associated
motor deficits akin to those observed in Parkinson's disease. Emerging evidence suggests …

Alzheimer's disease (AD) is affecting more and more human beings all over the world,
increasing exponentially the number of patients suffering from this neurodegenerative …