[HTML][HTML] Introduction to traditional medicine and their role in prevention and treatment of emerging and re-emerging diseases

SAA Rizvi, GP Einstein, OL Tulp, F Sainvil, R Branly - Biomolecules, 2022 - mdpi.com
Infectious diseases have been a threat to human health globally. The relentless efforts and
research have enabled us to overcome most of the diseases through the use of antiviral and …

[HTML][HTML] COVID-19 rebound after Paxlovid treatment: a case series and review of literature

S Alshanqeeti, A Bhargava - Cureus, 2022 - ncbi.nlm.nih.gov
Since the declaration of COVID-19 as a pandemic in 2020, several therapies have been
developed to reduce symptoms of COVID-19 infection and prevent progression. Paxlovid is …

[HTML][HTML] A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP)

T Starkey, MC Ionescu, M Tilby, M Little, E Burke… - Scientific Reports, 2023 - nature.com
Patients with cancer are at increased risk of hospitalisation and mortality following severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the SARS-CoV …

[HTML][HTML] A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations

J Ou, EM Lewandowski, Y Hu, AA Lipinski… - PLoS …, 2023 - journals.plos.org
The SARS-CoV-2 main protease (Mpro) is a major therapeutic target. The Mpro inhibitor,
nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID …

[HTML][HTML] Efficacy and safety evaluation of Azvudine in the prospective treatment of COVID-19 based on four phase III clinical trials

KW Zhu - Frontiers in Pharmacology, 2023 - frontiersin.org
Azvudine (FNC) is a synthetic nucleoside analog used to treat adult patients living with
human immunodeficiency virus-1 (HIV-1) infection with high viral load. After …

SARS-CoV-2 main protease (3CLpro) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking

S Mohandoss, R Sukanya, S Ganesan… - Journal of molecular …, 2022 - Elsevier
During the current outbreak of the novel coronavirus disease 2019 (COVID-19), researchers
have examined several antiviral drugs with the potential to inhibit the proliferation of the …

On the origins of SARS-CoV-2 main protease inhibitors

YL Janin - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
In order to address the world-wide health challenge caused by the COVID-19 pandemic, the
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …

Discovery of druggable potent inhibitors of serine proteases and farnesoid X receptor by ligand-based virtual screening to obstruct SARS-CoV-2

S Zaib, N Rana, HS Ali, N Hussain, HA Ogaly… - International Journal of …, 2023 - Elsevier
The coronavirus, a subfamily of the coronavirinae family, is an RNA virus with over 40
variations that can infect humans, non-human mammals and birds. There are seven types of …

[HTML][HTML] Glycyrrhizin and boswellic acids, the golden nutraceuticals: multitargeting for treatment of mild–moderate COVID-19 and prevention of post-COVID cognitive …

AA Gomaa, YA Abdel-Wadood, MA Gomaa - Inflammopharmacology, 2022 - Springer
Breakthrough infections have been reported in fully vaccinated persons. Furthermore,
rebound symptoms have been reported following the new FDA granted emergency use to …

[HTML][HTML] A retrospective study of Pupingqinghua prescription versus Lianhuaqingwen in Chinese participants infected with SARS-CoV-2 Omicron variants

Y Dong, W Zhai, B Fang, C Liu, S Yuan… - Frontiers in …, 2022 - frontiersin.org
Background: Coronavirus disease (COVID-19) seriously endangers global public health.
Pupingqinghua prescription (PPQH) is an herbal formula from traditional Chinese medicine …