Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Malaria vaccines: a new era of prevention and control

PE Duffy, JP Gorres, SA Healy, M Fried - Nature Reviews Microbiology, 2024 - nature.com
Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …

Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine

R Ma, ND Salinas, S Orr-Gonzalez… - PLoS …, 2024 - journals.plos.org
Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …

Safety and efficacy of PfSPZ Vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomised, double-blind, placebo-controlled …

H Diawara, SA Healy, A Mwakingwe-Omari… - The Lancet Infectious …, 2024 - thelancet.com
Background Plasmodium falciparum parasitaemia during pregnancy causes maternal, fetal,
and infant mortality. Poor pregnancy outcomes are related to blood-stage parasite …

Pregnancy and malaria: the perfect storm

SJ Rogerson, HW Unger - Current Opinion in Infectious Diseases, 2022 - journals.lww.com
Pregnancy and malaria: the perfect storm : Current Opinion in Infectious Diseases Pregnancy
and malaria: the perfect storm : Current Opinion in Infectious Diseases Log in or Register …

Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1. 4 broadly reacting with polymorphic malarial protein VAR2CSA

SSR Raghavan, R Dagil, M Lopez-Perez… - PLoS …, 2022 - journals.plos.org
Malaria during pregnancy is a major global health problem caused by infection with
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …

A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?

JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …

Detection of naturally acquired, strain-transcending antibodies against rosetting Plasmodium falciparum strains in humans

FE McLean, Y Azasi, C Sutherland, E Toboh… - Infection and …, 2024 - Am Soc Microbiol
Strain-transcending antibodies against virulence-associated subsets of P. falciparum-
infected erythrocyte surface antigens could protect children from severe malaria. However …

Analysis of allelic cross-reactivity of monoclonal IgG antibodies by a multiplexed reverse FluoroSpot assay

H Hoffmann-Veltung, NG Anabire, MF Ofori… - Elife, 2022 - elifesciences.org
The issue of antibody cross-reactivity is of central importance in immunology, and not least
in protective immunity to Plasmodium falciparum malaria, where key antigens show …

Malaria in pregnancy: adverse pregnancy outcomes and the future of prevention

AD Berhe, JYA Doritchamou, PE Duffy - Frontiers in Tropical …, 2023 - frontiersin.org
Malaria in pregnancy (MiP) poses a dangerous health risk to both mothers and their fetuses,
causing severe outcomes such as preterm delivery, intrauterine growth restriction …