Pathogenicity and virulence of malaria: Sticky problems and tricky solutions
IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …
each year, concentrated in Africa and in young children, but much of the world's population …
Malaria vaccines: a new era of prevention and control
Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …
Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
R Ma, ND Salinas, S Orr-Gonzalez… - PLoS …, 2024 - journals.plos.org
Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …
Safety and efficacy of PfSPZ Vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomised, double-blind, placebo-controlled …
H Diawara, SA Healy, A Mwakingwe-Omari… - The Lancet Infectious …, 2024 - thelancet.com
Background Plasmodium falciparum parasitaemia during pregnancy causes maternal, fetal,
and infant mortality. Poor pregnancy outcomes are related to blood-stage parasite …
and infant mortality. Poor pregnancy outcomes are related to blood-stage parasite …
Pregnancy and malaria: the perfect storm
SJ Rogerson, HW Unger - Current Opinion in Infectious Diseases, 2022 - journals.lww.com
Pregnancy and malaria: the perfect storm : Current Opinion in Infectious Diseases Pregnancy
and malaria: the perfect storm : Current Opinion in Infectious Diseases Log in or Register …
and malaria: the perfect storm : Current Opinion in Infectious Diseases Log in or Register …
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1. 4 broadly reacting with polymorphic malarial protein VAR2CSA
Malaria during pregnancy is a major global health problem caused by infection with
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …
A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
Detection of naturally acquired, strain-transcending antibodies against rosetting Plasmodium falciparum strains in humans
FE McLean, Y Azasi, C Sutherland, E Toboh… - Infection and …, 2024 - Am Soc Microbiol
Strain-transcending antibodies against virulence-associated subsets of P. falciparum-
infected erythrocyte surface antigens could protect children from severe malaria. However …
infected erythrocyte surface antigens could protect children from severe malaria. However …
Analysis of allelic cross-reactivity of monoclonal IgG antibodies by a multiplexed reverse FluoroSpot assay
H Hoffmann-Veltung, NG Anabire, MF Ofori… - Elife, 2022 - elifesciences.org
The issue of antibody cross-reactivity is of central importance in immunology, and not least
in protective immunity to Plasmodium falciparum malaria, where key antigens show …
in protective immunity to Plasmodium falciparum malaria, where key antigens show …
Malaria in pregnancy: adverse pregnancy outcomes and the future of prevention
AD Berhe, JYA Doritchamou, PE Duffy - Frontiers in Tropical …, 2023 - frontiersin.org
Malaria in pregnancy (MiP) poses a dangerous health risk to both mothers and their fetuses,
causing severe outcomes such as preterm delivery, intrauterine growth restriction …
causing severe outcomes such as preterm delivery, intrauterine growth restriction …