Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …

Aromatase inhibition is an efficient endocrine therapy to block ectopic estrogen production
for postmenopausal estrogen receptor (ER)-positive breast cancer patients, but many …

Introduction The progression and clinical course of head and neck squamous cell carcinoma
(HNSCC) relies on complex interactions between cancer and stromal cells in the tumor …

Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the
initiation of the immune response. The increased level of this cytokine in the elderly seems …

The tumor microenvironment (TME) corresponds to a complex and dynamic interconnection
between the extracellular matrix and malignant cells and their surrounding stroma …

Abstract Background Immune-related genes (IRGs) were linked to the prognosis of head
and neck squamous cell carcinoma (HNSCC). This study aimed to identify the effects of an …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

Cancer-associated fibroblasts (CAFs) are an essential component of the tumour
microenvironment. They represent a heterogeneous group of cells that are under the control …

The immunosuppressive tumor microenvironment plays an essential role in the treatment of
head and neck squamous cell carcinoma (HNSC). Compared to traditional …