Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and
represent a potential treatment for a variety of neurodegenerative and neurological …

Alzheimer's disease (AD) is a biologically complex neurodegenerative dementia. Nearly 20
years ago, with the combination of observations from biochemistry, neuropathology and …

In order to better understand the pathogenesis of Parkinson's Disease (PD) it is important to
consider possible contributory factors inherent to the aging process, as age-related changes …

The integrity of our genetic material is under constant attack from numerous endogenous
and exogenous agents. The consequences of a defective DNA damage response are well …

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

The past two decades have witnessed remarkable advances in oxidative stress research,
particularly in the context of ischemic brain injury. Oxidative stress in ischemic tissues …

The health benefits of fish oil, and its omega-3 long chain polyunsaturated fatty acid content,
have attracted much scientific attention in the last four decades. Fish oils that contain higher …

This perspective reviews the many dimensions of base excision repair from a 10,000 foot
vantage point and provides one person's view on where the field is headed. Enzyme …

The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …