Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk
factor for development of obesity and its complications, such as fatty liver disease and …

While virtually absent in our diet a few hundred years ago, fructose has now become a major
constituent of our modern diet. Our main sources of fructose are sucrose from beet or cane …

Although fructose consumption has dramatically increased and is suspected to be causally
linked to metabolic abnormalities, the mechanisms involved are still only partially …

Normal insulin secretion is oscillatory in vivo and in vitro, with a period of∼ 5–10 min. The
mechanism of generating these oscillations is not yet established, but a metabolic basis …

Metabolic reprogramming is a hallmark of cancer development, progression, and
metastasis. Several metabolic pathways such as glycolysis, tricarboxylic acid (TCA) cycle …

Congestive heart failure is a condition associated with increased plasma norepinephrine
levels, which have been demonstrated to impair glucose handling. In the present study, 10 …

Carbohydrate availability in the form of muscle and liver glycogen is an important
determinant of performance during prolonged bouts of moderate-to high-intensity exercise …

There are elevated fatty acid levels in non-insulin-dependent diabetes mellitus that are due
to diminished insulin action in inhibiting fatty acid release from adipocytes. Insulin therapy …

Pancreatic islets of Langerhans produce bursts of electrical activity when exposed to
stimulatory glucose levels. These bursts often have a regular repeating pattern, with a period …

The knowledge of the mechanism whereby glucose and other fuel stimuli promote the
release of insulin by the pancreatic beta cell remains fragmentary. The closure of …