Recent advances in intranasal liposomes for drug, gene, and vaccine delivery
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles
produced from cholesterol and phospholipids. Recently, liposomes have been widely …
produced from cholesterol and phospholipids. Recently, liposomes have been widely …
Mucosal SARS-CoV-2 nanoparticle vaccine based on mucosal adjuvants and its immune effectiveness by intranasal administration
L Xiao, W Yu, L Shen, W Yan, J Qi… - ACS Applied Materials & …, 2023 - ACS Publications
SARS-CoV-2 is a respiratory virus that causes significant threats to human health. Mucosal
immunity provides a first-line defense to prevent the infection of SARS-CoV-2 in the …
immunity provides a first-line defense to prevent the infection of SARS-CoV-2 in the …
Enhanced mucosal immune responses and reduced viral load in the respiratory tract of ferrets to intranasal lipid nanoparticle-based SARS-CoV-2 proteins and mRNA …
Background Unlike the injectable vaccines, intranasal lipid nanoparticle (NP)-based
adjuvanted vaccine is promising to protect against local infection and viral transmission …
adjuvanted vaccine is promising to protect against local infection and viral transmission …
Antiviral effect of SARS-CoV-2 N-specific CD8+ T cells induced in lungs by engineered extracellular vesicles
F Manfredi, C Chiozzini, F Ferrantelli, P Leone… - npj Vaccines, 2023 - nature.com
Induction of effective immunity in the lungs should be a requisite for any vaccine designed to
control the severe pathogenic effects generated by respiratory infectious agents. We recently …
control the severe pathogenic effects generated by respiratory infectious agents. We recently …
[HTML][HTML] One-year antibody durability induced by EuCorVac-19, a liposome-displayed COVID-19 receptor binding domain subunit vaccine, in healthy Korean subjects
JF Lovell, K Miura, YO Baik, C Lee, JY Lee… - International Journal of …, 2024 - Elsevier
Abstract Objective EuCorVac-19 (ECV-19), an adjuvanted liposome-displayed receptor
binding domain (RBD) COVID-19 vaccine, previously reported interim Phase 2 trial results …
binding domain (RBD) COVID-19 vaccine, previously reported interim Phase 2 trial results …
Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens
Abstract Background Enterotoxigenic Escherichia coli (ETEC) strains cause infectious
diarrhea and colonize host intestine epithelia via surface-expressed colonization factors …
diarrhea and colonize host intestine epithelia via surface-expressed colonization factors …
A pentavalent peptide vaccine elicits Aβ and tau antibodies with prophylactic activity in an Alzheimer's disease mouse model
Amyloid-β (Aβ) and hyperphosphorylated tau protein are targets for Alzheimer's Disease
(AD) immunotherapies, which are generally focused on single epitopes within Aβ or tau …
(AD) immunotherapies, which are generally focused on single epitopes within Aβ or tau …
SARS‐CoV‐2 Protein Nanoparticle Vaccines Formed In Situ From Lyophilized Lipids
The receptor binding domain (RBD) of the SARS‐CoV‐2 Spike (S) glycoprotein is an
appealing immunogen, but associated vaccine approaches must overcome the hapten‐like …
appealing immunogen, but associated vaccine approaches must overcome the hapten‐like …
Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein Antigens
The emergence of vaccine-evading SARS-CoV-2 variants urges the need for vaccines that
elicit broadly neutralizing antibodies (bnAbs). Here, we assess covalently circularized …
elicit broadly neutralizing antibodies (bnAbs). Here, we assess covalently circularized …
Displaying alphavirus physicochemical consensus antigens on immunogenic liposomes enhances antibody elicitation in mice
Cobalt-porphyrin phospholipid displays recombinant protein antigens on liposome surfaces
via antigen polyhistidine-tag (His-tag), and when combined with monophosphorylated lipid …
via antigen polyhistidine-tag (His-tag), and when combined with monophosphorylated lipid …