Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …

Although p53-mediated cell-cycle arrest, senescence and apoptosis serve as critical barriers
to cancer development, emerging evidence suggests that the metabolic activities of p53 are …

Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …

The non-essential amino acids serine and glycine are used in multiple anabolic processes
that support cancer cell growth and proliferation (reviewed in ref.). While some cancer cells …

Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …