Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal
cell death and the release of factors such as damage-associated molecular patterns …

Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …

Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

The CNS is protected by the immune system, including cells that reside directly within the
CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with …

Ischaemic stroke elicits a strong neuroinflammatory response, but the functional relevance
and therapeutic potential of neuroinflammation has only recently become apparent. In acute …

Background Neuroinflammation and immune responses occurring minutes to hours after
stroke are associated with brain injury after acute ischemic stroke (AIS). PPARγ coactivator …

Stroke is a primary cause of death and disability worldwide, while effective and safe drugs
remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle …

Rational design of potent antioxidative agent with high biocompatibility is urgently needed to
treat ischemic reperfusion-induced ROS-mediated cerebrovascular and neural injury during …

Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and
sensed by nucleic acid‐sensing pattern recognition receptors. We study the inflammatory …

Background and Purpose—White matter (WM) ischemic injury, a major neuropathological
feature of cerebral small vessel diseases, is an important cause of vascular cognitive …