Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …

Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

Diabetes mellitus is a chronic metabolic disease with a proinflammatory microenvironment,
causing poor vascularization and bone regeneration. Due to the lack of effective therapy and …

The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March …

Background Previous research has linked elevated low-density lipoprotein cholesterol (LDL-
C) and remnant cholesterol (RC) with diabetes mellitus (DM). The present study aims to …

Diabetes mellitus is defined as prolonged hyperglycemia, which can harm the eyes, kidneys,
and cardiovascular and neurological systems. Herbal agents and their derived supplements …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …