3D collagen fibrillar microstructure guides pancreatic cancer cell phenotype and serves as a critical design parameter for phenotypic models of EMT

TJ Puls, X Tan, CF Whittington, SL Voytik-Harbin - PloS one, 2017 - journals.plos.org
Pancreatic cancer, one of the deadliest cancers, is characterized by high rates of metastasis
and intense desmoplasia, both of which are associated with changes in fibrillar type I …

Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review

T Koltai, SJ Reshkin, TMA Carvalho, D Di Molfetta… - Cancers, 2022 - mdpi.com
Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

Biodistribution and in Vivo Activities of Tumor-Associated Macrophage-Targeting Nanoparticles Incorporated with Doxorubicin

M Niu, YW Naguib, AM Aldayel, Y Shi… - Molecular …, 2014 - ACS Publications
Tumor-associated macrophages (TAMs) are increasingly considered a viable target for
tumor imaging and therapy. Previously, we reported that innovative surface-functionalization …

MUC1: a novel metabolic master regulator

K Mehla, PK Singh - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2014 - Elsevier
MUC1, a type I transmembrane protein, is significantly overexpressed and aberrantly
glycosylated in tumors of epithelial origin. By virtue of its aberrant signaling due to loss of …

Tumor microenvironment features and chemoresistance in pancreatic ductal adenocarcinoma: Insights into targeting physicochemical barriers and metabolism as …

TMA Carvalho, D Di Molfetta, MR Greco, T Koltai… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor
prognosis. The lack of early diagnosis and the absence of suitable biomarkers coupled with …

Magnetic nanoparticle hyperthermia for treating locally advanced unresectable and borderline resectable pancreatic cancers: The role of tumor size and eddy-current …

A Attaluri, SK Kandala, H Zhou, M Wabler… - International Journal …, 2020 - Taylor & Francis
Purpose Tumor volume largely determines the success of local control of borderline
resectable and locally advanced pancreatic cancer with current therapy. We hypothesized …

Angiogenesis inhibitors and immunomodulation in renal cell cancers: the past, present, and future

L Kasherman, DHW Siu, R Woodford, CA Harris - Cancers, 2022 - mdpi.com
Simple Summary In their advanced stages, the mainstay of kidney cancer treatment is with
medications such as targeted or immune therapies. Breakthroughs in scientific …

Up-regulation of N-cadherin by collagen I-activated discoidin domain receptor 1 in pancreatic cancer requires the adaptor molecule Shc1

H Huang, RA Svoboda, AJ Lazenby, J Saowapa… - Journal of Biological …, 2016 - ASBMB
Pancreatic ductal adenocarcinomas are highly malignant cancers characterized by
extensive invasion into surrounding tissues, metastasis to distant organs, and a limited …

Feasibility of magnetic resonance elastography for the pancreas at 3T

Y Itoh, Y Takehara, T Kawase… - Journal of Magnetic …, 2016 - Wiley Online Library
Purpose 1) To assess the usefulness of an elastic belt bracing the upper abdomen for
reducing the miscalculated areas of the pancreas on 3.0 T magnetic resonance …

Mitochondrial DNA and mitomir variations in pancreatic cancer: potential diagnostic and prognostic biomarkers

L Moro - International Journal of Molecular Sciences, 2021 - mdpi.com
Pancreatic cancer is an aggressive disease with poor prognosis. Only about 15–20% of
patients diagnosed with pancreatic cancer can undergo surgical resection, while the …