Modification of proteins by glycans plays a crucial role in mediating biological functions in
both healthy and diseased states. Mass spectrometry (MS) has emerged as the most …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease
that develops relatively symptom-free and is therefore advanced at the time of diagnosis …

Cancer is a highly prevalent and potentially terminal disease that affects millions of
individuals worldwide. Here, we review the literature exploring the intricacies of stem cells …

Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor. Prognosis
is poor and survival is low in patients diagnosed with this disease, with a survival rate of …

Introduction The prognosis of patients with advanced pancreatic ductal adenocarcinoma
(PDAC) is dismal and conventional chemotherapy treatment delivers limited survival …

Desmoplasia plays a pivotal role in promoting pancreatic cancer progression and is
associated with poor clinical outcome. Targeting the desmoplastic tumor microenvironment …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by high
expression of extracellular matrix in tumor tissue, which contributes to chemoresistance and …

Progress in the treatment of patients with pancreatic cancer at earlier stages has motivated
research in identifying novel noninvasive or minimally invasive biomarkers for early …

Highlights•A novel in vitro platform for pancreatic cancer drug discovery is
suggested.•Design parameters for a pancreatic tumour-like construct are …

Background T cell exhaustion and activation markers are helpful in determining the
therapies and predicting the overall survival in pancreatic cancer (PC) patients. Purpose In …