Pancreatic cancer (Pa) is generally a very aggressive disease, with few effective
approaches available for early diagnosis or therapy. These factors, combined with the …

Highlights•Desmoplasia comprises of cellular and acellular components causing hindrance
to chemotherapy.•Decreased elasticity and increased interstitial fluid pressure deters drug …

In vitro cell models play important roles as testbeds for toxicity studies, drug development, or
as replacements in animal experiments. In particular, complex tumor models such as …

Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options.
We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor …

Pancreatic ductal adenocarcinoma (PDAC) remains a very difficult cancer to treat. Recent in
vitro and in vivo studies suggest that the activation of the receptor for advanced glycation …

Background/Aim: The aim of the study was to evaluate the status of extravasated platelet
activation (EPA) surrounding podoplanin (PDPN)-positive cancer-associated fibroblasts …

Pancreatic cancer is a highly lethal disease. Excessive accumulation of tumor extracellular
matrix (ECM) and epithelial-to-mesenchymal transition (EMT) phenotype are two main …

Blood-perfused tissue models are joining the emerging field of tumor engineering because
they provide new avenues for modulation of the tumor microenvironment and preclinical …

Decades of basic and translational studies have identified the mechanisms by which
pancreatic cancer cells use molecular pathways to hijack the normal homeostasis of the …

Therapeutic targeting of HA is therefore an attractive strategy, particularly in pancreatic
ductal adenocarcinoma (PDA), which is associated with an extremely poor prognosis and …