[HTML][HTML] The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer
YM Hashim, S Vangveravong, NV Sankpal… - Journal of Experimental …, 2017 - Springer
Background Pancreatic cancer is a lethal malignancy that frequently acquires resistance to
conventional chemotherapies often associated with overexpression of inhibitors of apoptosis …
conventional chemotherapies often associated with overexpression of inhibitors of apoptosis …
Duodenal ischemia and upper GI bleeding are dose-limiting toxicities of 24-h continuous intra-arterial pancreatic perfusion of gemcitabine following vascular isolation …
JD Beane, KF Griffin, EB Levy, P Pandalai… - Investigational new …, 2015 - Springer
Background Regional chemotherapy is used successfully in the treatment of both primary
and secondary malignancies, in particular of the peritoneal surface and the liver, and is …
and secondary malignancies, in particular of the peritoneal surface and the liver, and is …
The pathologic diagnosis of carcinoma in various tissues
A Avery, J Alden, C Kramish, C Caballero… - Advances in cancer …, 2022 - Elsevier
Carcinoma is defined as cancer arising from the epithelial cells that line an organ or tissue.
The most common carcinoma in males arises in the prostate and breast in females; while the …
The most common carcinoma in males arises in the prostate and breast in females; while the …
CAR‐T cell therapy
J Franklin, P Pophali, Z Jackson, D Wald… - Molecular …, 2024 - Wiley Online Library
CAR‐T cell therapy has transformed outcomes for patients with lymphoproliferative
malignancies including diffuse large B‐cell lymphoma and multiple myeloma. CAR‐T cells …
malignancies including diffuse large B‐cell lymphoma and multiple myeloma. CAR‐T cells …
[HTML][HTML] Pancreatic biomarkers: Could they be the answer?
A Lamarca, J Feliu - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDA) is known for its poor prognosis. Most of the
patients are diagnosed with advanced stages, when no curative treatment is available …
patients are diagnosed with advanced stages, when no curative treatment is available …
[HTML][HTML] P-glycoprotein associated with diabetes mellitus and survival of patients with pancreatic cancer: 8-year follow-up
N Hu, H Wang, Q Qian, Y Jiang, J Xie… - Brazilian Journal of …, 2020 - SciELO Brasil
Diabetes mellitus (DM) has a high prevalence in patients with pancreatic cancer (PaC), but
the prognostic value of DM in PaC remains controversial. Alterations of P-glycoprotein (P …
the prognostic value of DM in PaC remains controversial. Alterations of P-glycoprotein (P …
[PDF][PDF] A non-covalent KRASG12D allele specific inhibitor demonstrates potent inhibition of KRAS-dependent signaling and regression of KRASG12D-mutant tumors
J Christensen, J Hallin, V Bowcut, A Calinisan, D Briere… - 2022 - academia.edu
The ability to effectively target mutated KRAS has remained elusive despite decades of
research. The recent identification of KRASG12C inhibitors has provided an effective …
research. The recent identification of KRASG12C inhibitors has provided an effective …
Co-treatment with a C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation
S Ishiguro, A Kawabata, A Zulbaran-Rojas… - Biochemical and …, 2018 - Elsevier
Although gemcitabine is an effective chemotherapeutic for pancreatic cancer, severe side
effects often accompany its use. Since we have discovered that locally administered C1B …
effects often accompany its use. Since we have discovered that locally administered C1B …
Matrix mechanics, not hypoxia, modulate quiescin sulfhydryl oxidase 1 (QSOX1) in pancreatic tumor cells
Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancer-related
deaths in the US, despite only being the 11th most common cancer. The high mortality rates …
deaths in the US, despite only being the 11th most common cancer. The high mortality rates …
[HTML][HTML] Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model
In this work, novel bioinspired polyurethane (PU) scaffolds were fabricated via freeze casting
for PU-based Pancreatic Ductal Adenocarcinoma (PDAC) model. In order to reproduce the …
for PU-based Pancreatic Ductal Adenocarcinoma (PDAC) model. In order to reproduce the …