Cancer is a leading cause of death globally, and cancer management continues to pose a
great challenge to modern medicine. Major efforts have been made to obtain a …

Current clinical approaches for treating pancreatic cancer have been demonstrated as
ineffective at improving midterm survival (< 10%). Plasmonic photothermal therapy (PPTT) …

Pancreatic ductal adenocarcinoma is a devastating disease with dismal survival rate and
limited treatment options. Conventional therapeutic approaches including gemcitabine …

Drug resistance is one of the principal limitations in clinical oncology and the cause of
recurrence in many patients. Resistance to conventional treatments makes it difficult to treat …

The tissue microenvironment is a complex living system containing heterogeneous
mechanical and biophysical cues. Cellular components are surrounded by extracellular …

The sonic hedgehog (SHH) signaling pathway is activated in a paracrine manner in
pancreatic ductal adenocarcinoma (PDAC), which mediates the formation of a fibroblast …

Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal
adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass, which acts as a …

Abstract The Pancreatic Ductal Adenocarcinoma is a malignant aggressive disease
corresponding to a low survival rate of 5 years, only between 5 to 7%. This is mainly due to …

Background and Aims: Over 80% of patients with pancreatic ductal adenocarcinoma (PDAC)
are diagnosed with concurrent metastases. Over the last 50 years, conventional treatment …

The tumor microenvironment (TME) is a complex, poorly understood component of tumor
biology. As cancer therapy continues to become more personalized for each patient based …