Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
K Blaschke, KT Ebata, MM Karimi, JA Zepeda-Martínez… - Nature, 2013 - nature.com
DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …
Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
DNA methylation has critical roles in the nervous system and has been traditionally
considered to be restricted to CpG dinucleotides in metazoan genomes. Here we show that …
considered to be restricted to CpG dinucleotides in metazoan genomes. Here we show that …
Epigenetic mechanisms in neurogenesis
In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
[HTML][HTML] The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
[HTML][HTML] Transcription factors drive Tet2-mediated enhancer demethylation to reprogram cell fate
Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …
[HTML][HTML] MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests
that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic …
that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic …
[HTML][HTML] Programming and inheritance of parental DNA methylomes in mammals
The reprogramming of parental methylomes is essential for embryonic development. In
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …
[HTML][HTML] Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells
ODK Maddocks, CF Labuschagne, PD Adams… - Molecular cell, 2016 - cell.com
Crosstalk between cellular metabolism and the epigenome regulates epigenetic and
metabolic homeostasis and normal cell behavior. Changes in cancer cell metabolism can …
metabolic homeostasis and normal cell behavior. Changes in cancer cell metabolism can …
Epigenetic modifications in cardiovascular aging and diseases
Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …
Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing
DNA methylation is crucial for a wide variety of biological processes, yet no technique
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …