Emerging single-cell epigenomic methods are being developed with the exciting potential to
transform our knowledge of gene regulation. Here we review available techniques and …

In mammalian development, epigenetic modifications, including DNA methylation patterns,
play a crucial role in defining cell fate but also represent epigenetic barriers that restrict …

DNA methylation is an important epigenetic modification,,. Ten-eleven translocation (TET)
proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine …

Cell identity is determined by specific gene expression patterns that are conveyed by
interactions between transcription factors and DNA in the context of chromatin. In …

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene
expression, and DNA methylation abnormalities are often observed in diseases. The ten …

DNA methylation in mammals is highly dynamic during germ cell and preimplantation
development but is relatively static during the development of somatic tissues. 5 …

In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is
notably depleted from active promoters and enhancers. While the role of DNA methylation in …

DNA and RNA modifications have important functions, including the regulation of gene
expression. Existing methods based on short-read sequencing for the detection of …

Molecular control of the pluripotent state is thought to reside in a core circuitry of master
transcription factors including the homeodomain-containing protein NANOG,, which has an …

DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …