Obstructive sleep disorders develop when the normal reduction in pharyngeal dilator activity
at sleep onset occurs in an individual whose pharynx requires a relatively high level of …

It is crucial to understand the underlying pathophysiology of obstructive sleep apnea (OSA).
Upper airway collapsibility is an important pathophysiological factor that affects the upper …

Although nasal surgery has limited efficacy in obstructive sleep apnoea (OSA) treatment,
some patients experience improvement. The present study tested the hypothesis that post …

Obesity is associated with alterations in upper airway collapsibility during sleep. Obese,
leptin-deficient mice demonstrate blunted ventilatory control, leading us to hypothesize that …

Rationale: Ventilatory motor output is an important determinant of upper airway patency
during sleep. Objectives: We hypothesized that central hypocapnic hypopnea would lead to …

Hypoglossal nerve stimulation (HNS) is an alternative treatment option for obstructive sleep
apnea (OSA) that reduces pharyngeal collapsibility, but HNS nonresponders often …

Abstract Study Objectives: Obstructive sleep apnea (OSA) is characterized by repetitive
pharyngeal collapse during sleep. However, the dynamics of pharyngeal narrowing and re …

Defects in pharyngeal mechanical and neuromuscular control are required for the
development of obstructive sleep apnea. Obesity and age are known sleep apnea risk …

Background Temporizing oxygenation by percutaneous transtracheal ventilation (PTV) is a
recommended emergency technique in 'can't intubate, can't oxygenate'(CICO) situations …

Increasing lung volume increases upper airway patency and decreases airway resistance
and collapsibility. The role of diaphragm contraction in producing these changes remains …