The importance of proteases during apoptosis is becoming increasingly apparent. Because
apoptosis contributes to a diverse variety of disease processes, understanding the roles …

Activation of the serine-threonine kinase p34cdc2 at an inappropriate time during the cell
cycle leads to cell death that resembles apoptosis. Premature activation of p34cdc2 was …

The molecular basis of programmed cell death (PCD) is unknown. An important clue is
provided by the Bcl‐2 protein, which can protect many cell types from PCD, although it is not …

Chromatin condensation paralleled by DNA fragmentation is one of the most important
criteria which are used to identify apoptotic cells. However, comparable changes are also …

A great deal of interest and effort has been recently focused on understanding the inner
workings of a particular style of cell death that occurs in variety of physiological settings. As …

We have developed a cell-free system that induces the morphological transformations
characteristic of apoptosis in isolated nuclei. The system uses extracts prepared from mitotic …

Apoptosis, or programmed cell death, is defined by morphologic change resulting in
nonpathologic cell loss and is relevant to a wide spectrum of biology. The process is best …

Cell death, a scheduled event during development and tissue turnover, or the ultimate
consequence of toxic or pathologic insults seems to involve a relatively limited number of …

Chemotherapeutic agents that target topoisomerase I and II set into motion a series of
biochemical changes that culminate in cell death, but only under some conditions. The …

We show here that the combination of interferon-β (IFN-β) and all-trans-retinoic acid (RA)
induces the death of tumor cells. To understand the molecular basis for synergistic growth …