The term apoptosis describes the predictable structural changes associated with many forms
of programmed cell death. One of the first visible events of apoptosis is the collapse of the …

The epidemiology and histopathology of human cancers and studies of animal models of
tumorigenesis have led to a widely-accepted notion that multiple genetic and epigenetic …

Apoptosis commonly occurs following the removal of growth factors from cells that are
dependent on them for their survival. Some examples are listed in Table II. In many eases …

The bcl‐2 gene product, a 25 kDa membrane protein residing at mitochondrial, microsomal
and nuclear membrane sites within many cell types, is a broad and potent inhibitor of cell …

In previous studies we showed that transforming growth factor-β1 induces apoptosis in
hepatocyte cultures and regressing livers, the mature form being more potent than the …

Apoptosis is an important physiological process that involves the deletion of specific cells in
a controlled and timely manner. A biochemical hallmark typifying apoptosis in normal …

Programmed cell death or apoptosis (Greek for the falling of the leafs in autumn) is an event
by which cells are deliberately eliminated (recently reviewed by Ucker 1991, Williams et al …

Much progress has been made in defining the mechanisms by which altered systolic and
diastolic function of the heart may be produced by components of the immune system …

TB/C3 hybridoma cells were transected with either pEF‐MClneopA or pEF bcl2‐MClneopA
vectors to produce a control cell line (TB/C3 pEF) and a cell line that overexpresses the …

Apoptosis is a major form of cell death induced by chemotherapeutic drugs. Overexpression
of the proto-oncogene bcl-2 can prevent apoptosis in various types of cells. We have …