Peripheral changes in endometriosis-associated pain

M Morotti, K Vincent, J Brawn… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND Pain remains the cardinal symptom of endometriosis. However, to date, the
underlying mechanisms are still only poorly understood. Increasing evidence points towards …

Dual therapy with anti‐CGRP monoclonal antibodies and botulinum toxin for migraine prevention: is there a rationale?

L Pellesi, TP Do, H Ashina, M Ashina… - … : The Journal of Head …, 2020 - Wiley Online Library
Objective To narratively review the pathophysiological rationale of dual therapy with anti‐
calcitonin gene‐related peptide monoclonal antibodies and botulinum toxin type A in …

Antagonism of CGRP receptor: central and peripheral mechanisms and mediators in an animal model of chronic migraine

R Greco, C Demartini, M Francavilla, AM Zanaboni… - Cells, 2022 - mdpi.com
Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …

[HTML][HTML] Vascular contributions to migraine: time to revisit?

BN Mason, AF Russo - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Migraine is one of the most prevalent and disabling neurovascular disorders worldwide.
However, despite the increase in awareness and research, the understanding of migraine …

Role of neuroinflammation and blood-brain barrier permutability on migraine

G Yamanaka, S Suzuki, N Morishita… - International journal of …, 2021 - mdpi.com
Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although
the efficacy of this method is limited and new treatment strategies are desired …

Calcitonin gene‐related peptide (CGRP) and migraine current understanding and state of development

ME Bigal, S Walter, AM Rapoport - Headache: The Journal of …, 2013 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) is a ubiquitous neuropeptide found at the very
centers of the migraine process, both centrally and peripherally. It has been under careful …

Menstruation pulls the trigger for inflammation and pain in endometriosis

A Laux-Biehlmann, T d'Hooghe, TM Zollner - Trends in pharmacological …, 2015 - cell.com
Endometriosis is a chronic, hormone-dependent, inflammatory disease, characterized by the
presence and growth of endometrial tissue outside the uterine cavity. It affects 5–10% of the …

Migraine and neuropeptides

J Tajti, D Szok, Z Majláth, B Tuka, A Csáti, L Vécsei - Neuropeptides, 2015 - Elsevier
Migraine is a common disabling neurovascular primary headache disorder. The
pathomechanism is not clear, but extensive preclinical and clinical studies are ongoing. The …

Vitamin D in migraine headache: a comprehensive review on literature

Z Ghorbani, M Togha, P Rafiee, ZS Ahmadi… - Neurological …, 2019 - Springer
Introduction As a primary headache, migraine has been established as the first leading
disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary …

Cortical spreading depression as a site of origin for migraine: Role of CGRP

LN Close, S Eftekhari, M Wang, AC Charles… - …, 2019 - journals.sagepub.com
Premise Migraine is a complex neurologic disorder that leads to significant disability, yet
remains poorly understood. Problem One potential triggering mechanism in migraine with …