[HTML][HTML] Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are
attractive targets for new analgesics. We made a permanently charged cationic derivative of …
attractive targets for new analgesics. We made a permanently charged cationic derivative of …
Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels
2012-08-07 Assigned to ALDERBIO HOLDINGS LLC reassignment ALDERBIO HOLDINGS
LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
Role of atogepant in the treatment of episodic migraines: clinical perspectives and considerations
Advances in molecular biology and neuroscience have led to the discovery of calcitonin
gene-related peptide (CGRP), a 37 amino-acid neuropeptide that plays a critical role in the …
gene-related peptide (CGRP), a 37 amino-acid neuropeptide that plays a critical role in the …
Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine
H Duarte, AL Teixeira, NP Rocha, RB Domingues - Neurological Sciences, 2015 - Springer
Inflammatory mediators have been studied in migraine pathophysiology; however, their role
is not yet well established. The aim of the present study was to investigate interictal …
is not yet well established. The aim of the present study was to investigate interictal …
A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine
B von Mentzer, AF Russo, Z Zhang… - Journal of pharmacy …, 2020 - academic.oup.com
Objectives To investigate the formulation of the peptide-based antagonist (34Pro, 35Phe)
CGRP27–37, of the human calcitonin gene-related peptide (CGRP) receptor as a potential …
CGRP27–37, of the human calcitonin gene-related peptide (CGRP) receptor as a potential …
Low frequency electroacupuncture alleviated spinal nerve ligation induced mechanical allodynia by inhibiting TRPV1 upregulation in ipsilateral undamaged dorsal …
YL Jiang, XH Yin, YF Shen, XF He… - Evidence‐Based …, 2013 - Wiley Online Library
Neuropathic pain is an intractable problem in clinical practice. Accumulating evidence
shows that electroacupuncture (EA) with low frequency can effectively relieve neuropathic …
shows that electroacupuncture (EA) with low frequency can effectively relieve neuropathic …
[HTML][HTML] Mechanosensitive receptors in migraine: a systematic review
A Della Pietra, L Gómez Dabó, P Mikulenka… - The Journal of …, 2024 - Springer
Background Migraine is a debilitating neurological disorder with pain profile, suggesting
exaggerated mechanosensation. Mechanosensitive receptors of different families, which …
exaggerated mechanosensation. Mechanosensitive receptors of different families, which …
The role of vasoactive neuropeptides in the genesis of venous pelvic pain: A review
SG Gavrilov, GY Vassilieva, IM Vasilev… - …, 2020 - journals.sagepub.com
Mechanisms of the development of pain in chronic venous diseases, including pelvic
congestion syndrome, are not studied in detail so far. The existing hypotheses of the …
congestion syndrome, are not studied in detail so far. The existing hypotheses of the …
Assessment of immunogenicity from galcanezumab phase 3 trials in patients with episodic or chronic migraine
JM Martinez, N Hindiyeh, G Anglin, K Kalidas… - …, 2020 - journals.sagepub.com
Background This analysis characterizes the immunogenicity profile of galcanezumab, a
humanized monoclonal antibody that selectively binds calcitonin gene-related peptide and …
humanized monoclonal antibody that selectively binds calcitonin gene-related peptide and …
[HTML][HTML] Effect of Paeonia lactiflora, a traditional Chinese herb, on migraines based on clinical application and animal behavior analyses
Background Paeonia lactiflora (PL) was widely used for pain relief, but its effects on
migraine headaches remain unclear. Purpose The aim of the present study was to …
migraine headaches remain unclear. Purpose The aim of the present study was to …