Major depression is a common, recurrent mental illness that affects millions of people
worldwide. Recently, a unique fast neuroprotective and antidepressant treatment effect has …

Guanosine is a purine nucleoside with important functions in cell metabolism and a
protective role in response to degenerative diseases or injury. The past decade has seen …

Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …

Inflammation, oxidative and nitrosative stress underlie depression being assessed in
rodents by the systemic administration of lipopolysacharide (LPS). There is an increasing …

The function of guanine-based purines (GBPs) is mostly attributed to the intracellular
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …

Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released
in the brain under physiological conditions and even more during pathological events …

The ability of the N-methyl-d-aspartate receptor antagonist ketamine to induce a rapid and
sustained antidepressant effect has led to a surge in pre-clinical studies investigating …

AZD6765 (lanicemine) is a non-competitive NMDA receptor antagonist that induces a fast-
acting antidepressant effect without presenting psychotomimetic effects. However, the …

Accumulating evidences indicate that endogenous modulators of excitatory synapses in the
mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed …

In the present review, we stress the importance of the purine nucleosides, adenosine and
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …