The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Keloids are disfiguring fibroproliferative lesions that can occur in susceptible individuals
following any skin injury. They are extremely challenging to treat, with relatively low …

Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids
exhibit some cancer-like behaviors, with similar genetic and epigenetic modifications in the …

Keloid is a disease in which fibroblasts abnormally proliferate and synthesize excessive
amounts of extracellular matrix, including collagen and fibronectin, during the healing …

Background Neovascular age-related macular degeneration (nAMD), accounts for up to
90% of AMD-associated vision loss, ultimately resulting in the formation of fibrotic scar in the …

Hypertrophic scars and keloids are common fibroproliferative diseases following injury.
Patients with pathologic scars suffer from impaired quality of life and psychological health …

Pathological scars or abnormal scars, which include hypertrophic scars and keloids, are
scar formations that sometimes occur during the wound healing process. The pathogenesis …

Overabundance of the extracellular matrix resulting from hyperproliferation of keloid
fibroblasts (KFs) and dysregulation of apoptosis represents the main pathophysiology …

Glaucoma valves (GVs) play an essential role in treating glaucoma. However, fibrosis after
implantation has limited their long-term success in clinical applications. In this study, we …

The Period (PER) gene family is one of the core components of the circadian clock, with
substantial correlations between the PER genes and cancers identified in extensive …