Objective—B cells promote or protect development of atherosclerosis. In this study, we
examined the role of MHCII (major histocompatibility II), CD40 (cluster of differentiation 40) …

Background Aberrant activation of the NLRP 3 (nucleotide‐binding oligomerization domain,
leucine‐rich repeat–containing receptor family pyrin domain‐containing 3) inflammasome is …

Although aging enhances atherosclerosis, we do not know if this occurs via alterations in
circulating immune cells, lipid metabolism, vasculature, or adipose tissue. Here, we …

Background: We previously showed that mice lacking MΦLRP1-/-(low-density lipoprotein
receptor–related protein 1 in macrophages) undergo accelerated atherosclerotic plaque …

Abstract Aims The variant p. Arg149Cys in ACTA2, which encodes smooth muscle cell
(SMC)-specific α-actin, predisposes to thoracic aortic disease and early onset coronary …

Objective: MR (mineralocorticoid receptor) activation is associated with cardiovascular
ischemia in humans. This study explores the role of the MR in atherosclerotic mice of both …

Cardiovascular diseases are often associated with impaired lipid metabolism. Animal
models are useful for deciphering the physiological mechanisms underlying these …

Objective: Calcification of atherosclerotic plaque is traditionally associated with increased
cardiovascular event risk; however, recent studies have found increased calcium density to …

Background and aims Our previous data showed that lymphatic function impairment occurs
before the onset of atherosclerosis in mice and is precociously associated with a defect in …

Background: Clinical studies show that the most common single-point mutation in humans,
ALDH2 (aldehyde dehydrogenase 2) rs671 mutation, is a risk factor for the development and …