Genetic Deficiency of Flavin-Containing Monooxygenase 3 (Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels—Brief Report

DM Shih, W Zhu, RC Schugar, Y Meng… - … , and vascular biology, 2019 - Am Heart Assoc
Objective—FMO (flavin-containing monooxygenase) 3 converts bacterial-derived
trimethylamine to trimethylamine N-oxide (TMAO), an independent risk factor for …

(−)-Epicatechin gallate blocks the development of atherosclerosis by regulating oxidative stress in vivo and in vitro

J Yu, W Li, X Xiao, Q Huang, J Yu, Y Yang, T Han… - Food & Function, 2021 - pubs.rsc.org
(−)-Epicatechin gallate (ECG), as a compound in green tea extract polyphenols, has specific
therapeutic effects against oxidative stress. Oxidative stress exists throughout the …

Endothelial Rap1 (Ras-association proximate 1) restricts inflammatory signaling to protect from the progression of atherosclerosis

B Singh, R Kosuru, S Lakshmikanthan… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Small GTPase Rap1 (Ras-association proximate 1) is a novel, positive regulator
of NO release and endothelial function with a potentially key role in mechanosensing of …

Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans

N Loaiza, ML Hartgers, LF Reeskamp… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: STAP1, encoding for STAP1 (signal transducing adaptor family member 1), has
been reported as a candidate gene associated with familial hypercholesterolemia. Unlike …

Atherosclerosis, periodontal disease, and treatment with resolvins

JA Hamilton, H Hasturk, A Kantarci, CN Serhan… - Current atherosclerosis …, 2017 - Springer
Abstract Purpose of Review This review aims to discuss the existing evidence on the link
between atherosclerosis and periodontitis by particularly presenting new findings that link …

[HTML][HTML] Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice

S Lee, H Schleer, H Park, E Jang, M Boyer… - Nature cardiovascular …, 2023 - nature.com
Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis
initiation and progression. Activin A receptor-like type 1 (ACVRL1, called activin-like kinase …

[HTML][HTML] The role of lymphatic vascular function in metabolic disorders

PR Norden, T Kume - Frontiers in Physiology, 2020 - frontiersin.org
In addition to its roles in the maintenance of interstitial fluid homeostasis and
immunosurveillance, the lymphatic system has a critical role in regulating transport of dietary …

[HTML][HTML] Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis

Z Li, Q Li, L Wang, C Li, M Xu, Y Duan, L Ma, T Li… - Redox biology, 2021 - Elsevier
Objective The disruption of mitochondrial redox homeostasis in endothelial cells (ECs) can
cause chronic inflammation, a substantial contributor to the development of atherosclerosis …

Inhibition of vascular calcification: a new antiatherogenic mechanism of topo II (DNA Topoisomerase II) inhibitors

L Liu, P Zeng, X Yang, Y Duan, W Zhang… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Vascular calcification is a major risk factor for rupture of atherosclerotic plaques.
High expression of BMP2 (bone morphogenetic protein 2) in lesions suggests its importance …

[HTML][HTML] CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins

M Shimizu-Albergine, D Basu… - The Journal of …, 2021 - Am Soc Clin Investig
Loss-of-function mutations in the transcription factor CREB3L3 (CREBH) associate with
severe hypertriglyceridemia in humans. CREBH is believed to lower plasma triglycerides by …