Genetic Deficiency of Flavin-Containing Monooxygenase 3 (Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels—Brief Report
DM Shih, W Zhu, RC Schugar, Y Meng… - … , and vascular biology, 2019 - Am Heart Assoc
Objective—FMO (flavin-containing monooxygenase) 3 converts bacterial-derived
trimethylamine to trimethylamine N-oxide (TMAO), an independent risk factor for …
trimethylamine to trimethylamine N-oxide (TMAO), an independent risk factor for …
(−)-Epicatechin gallate blocks the development of atherosclerosis by regulating oxidative stress in vivo and in vitro
J Yu, W Li, X Xiao, Q Huang, J Yu, Y Yang, T Han… - Food & Function, 2021 - pubs.rsc.org
(−)-Epicatechin gallate (ECG), as a compound in green tea extract polyphenols, has specific
therapeutic effects against oxidative stress. Oxidative stress exists throughout the …
therapeutic effects against oxidative stress. Oxidative stress exists throughout the …
Endothelial Rap1 (Ras-association proximate 1) restricts inflammatory signaling to protect from the progression of atherosclerosis
Objective: Small GTPase Rap1 (Ras-association proximate 1) is a novel, positive regulator
of NO release and endothelial function with a potentially key role in mechanosensing of …
of NO release and endothelial function with a potentially key role in mechanosensing of …
Taking One Step Back in Familial Hypercholesterolemia: STAP1 Does Not Alter Plasma LDL (Low-Density Lipoprotein) Cholesterol in Mice and Humans
N Loaiza, ML Hartgers, LF Reeskamp… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: STAP1, encoding for STAP1 (signal transducing adaptor family member 1), has
been reported as a candidate gene associated with familial hypercholesterolemia. Unlike …
been reported as a candidate gene associated with familial hypercholesterolemia. Unlike …
Atherosclerosis, periodontal disease, and treatment with resolvins
Abstract Purpose of Review This review aims to discuss the existing evidence on the link
between atherosclerosis and periodontitis by particularly presenting new findings that link …
between atherosclerosis and periodontitis by particularly presenting new findings that link …
[HTML][HTML] Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice
Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis
initiation and progression. Activin A receptor-like type 1 (ACVRL1, called activin-like kinase …
initiation and progression. Activin A receptor-like type 1 (ACVRL1, called activin-like kinase …
[HTML][HTML] The role of lymphatic vascular function in metabolic disorders
In addition to its roles in the maintenance of interstitial fluid homeostasis and
immunosurveillance, the lymphatic system has a critical role in regulating transport of dietary …
immunosurveillance, the lymphatic system has a critical role in regulating transport of dietary …
[HTML][HTML] Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis
Z Li, Q Li, L Wang, C Li, M Xu, Y Duan, L Ma, T Li… - Redox biology, 2021 - Elsevier
Objective The disruption of mitochondrial redox homeostasis in endothelial cells (ECs) can
cause chronic inflammation, a substantial contributor to the development of atherosclerosis …
cause chronic inflammation, a substantial contributor to the development of atherosclerosis …
Inhibition of vascular calcification: a new antiatherogenic mechanism of topo II (DNA Topoisomerase II) inhibitors
L Liu, P Zeng, X Yang, Y Duan, W Zhang… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Vascular calcification is a major risk factor for rupture of atherosclerotic plaques.
High expression of BMP2 (bone morphogenetic protein 2) in lesions suggests its importance …
High expression of BMP2 (bone morphogenetic protein 2) in lesions suggests its importance …
[HTML][HTML] CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins
M Shimizu-Albergine, D Basu… - The Journal of …, 2021 - Am Soc Clin Investig
Loss-of-function mutations in the transcription factor CREB3L3 (CREBH) associate with
severe hypertriglyceridemia in humans. CREBH is believed to lower plasma triglycerides by …
severe hypertriglyceridemia in humans. CREBH is believed to lower plasma triglycerides by …