ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the
clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a …

Background The presence of foamy macrophages and microglia containing intracellular
myelin remnants is a pathological hallmark of neurodegenerative disorders such as multiple …

Cholesterol is an essential component of all cell membranes and particularly enriched in
myelin membranes. Myelin membranes are a major target of immune attacks in the chronic …

Parkinson's disease (PD) is a neurodegenerative disease due to the degeneration of
dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is …

Matrix-assisted laser desorption/ionisation-mass spectrometry imaging (MALDI-MSI) is a
powerful technique for visualising the spatial locations of lipids in biological tissues …

Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune,
inflammatory and neurodegenerative processes leading to neuronal demyelination and …